7-methoxy-5-(2-methoxybenzoyl)-2,2-dimethyl-4H-anthra[2,3-d][1,3]dioxine-4,6,11-trione | 877775-39-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 7-methoxy-5-(2-methoxybenzoyl)-2,2-dimethyl-4H-anthra[2,3-d][1,3]dioxine-4,6,11-trione
• 英文别名: 7-Methoxy-5-(2-methoxybenzoyl)-2,2-dimethylnaphtho[3,2-g][1,3]benzodioxine-4,6,11-trione
• CAS: 877775-39-8
• 化学式: C₂₇H₂₀O₈
• 分子量: 472.451
• InChiKey: HDORMUUCMABZET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  35
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  105
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  7-methoxy-5-(2-methoxybenzoyl)-2,2-dimethyl-4H-anthra[2,3-d][1,3]dioxine-4,6,11-trione 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以95%的产率得到5-(2-hydroxybenzoyl)-7-methoxy-2,2-dimethyl-4H-anthra[2,3-d][1,3]dioxine-4,6,11-trione
  参考文献：
  名称：

  Synthesis of 2′-dealkylmumbaistatin

  摘要：

  The sterically congested 1,2,3-substituted 3'-dealkyl mumbaistatin derivatives 16, 20, and 21 were prepared for the first time by base-catalyzed cyclization of the 2,3-bis-substituted naphthoquinone precursor 11 followed by bromine mediated photooxidation and methyl ether cleavage. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.10.063
• 作为产物：
  描述：

  2-[(2,2-dimethyl-6-oxo-6H-1,3-dioxin-4-yl)methyl]-5-methoxy-3-[2-(2-methoxypnenyl)acetyl]-1,4-naphthoquinone 在 水 、 溴 、 potassium carbonate 、 calcium chloride 作用下， 以 甲醇 、 四氯化碳 为溶剂， 反应 24.0h， 生成 7-methoxy-5-(2-methoxybenzoyl)-2,2-dimethyl-4H-anthra[2,3-d][1,3]dioxine-4,6,11-trione
  参考文献：
  名称：

  Synthesis of 2′-dealkylmumbaistatin

  摘要：

  The sterically congested 1,2,3-substituted 3'-dealkyl mumbaistatin derivatives 16, 20, and 21 were prepared for the first time by base-catalyzed cyclization of the 2,3-bis-substituted naphthoquinone precursor 11 followed by bromine mediated photooxidation and methyl ether cleavage. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.10.063

文献信息

• Synthesis of 2′-dealkylmumbaistatin
  作者：Karsten Krohn、Jan Diederichs、Muhammad Riaz

  DOI：10.1016/j.tet.2005.10.063

  日期：2006.2

  The sterically congested 1,2,3-substituted 3'-dealkyl mumbaistatin derivatives 16, 20, and 21 were prepared for the first time by base-catalyzed cyclization of the 2,3-bis-substituted naphthoquinone precursor 11 followed by bromine mediated photooxidation and methyl ether cleavage. (c) 2005 Elsevier Ltd. All rights reserved.