3,2',3',4'-tetramethoxybiphenyl-4-ol | 1313547-60-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,2',3',4'-tetramethoxybiphenyl-4-ol
• 英文别名: 2-Methoxy-4-(2,3,4-trimethoxyphenyl)phenol
• CAS: 1313547-60-2
• 化学式: C₁₆H₁₈O₅
• 分子量: 290.316
• InChiKey: WVNAMCTZUAWVMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  57.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-溴邻甲氧基苯酚 、 2,3,4-三甲氧基苯硼酸 在 2-[2-(diisobutylphosphinyl)ethyl]pyridine 、 palladium diacetate 、 caesium carbonate 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以60%的产率得到3,2',3',4'-tetramethoxybiphenyl-4-ol
  参考文献：
  名称：

  一步进入P，O和P，N型杂环叔膦配体及其在Suzuki-Miyaura交叉偶联反应中的应用。

  摘要：

  描述了构象可移动的P，O-和P，N-型杂环膦配体的直接合成，包括自由基介导的二异丁基膦加成至烯烃-杂环。经测定，P，N-配体的钯配合物在Suzuki-Miyaura交叉偶联反应（包括失活的芳基氯化物）中具有很高的活性。

  DOI：

  10.1039/c1ob05426k

文献信息

• One step entry to P,O- and P,N-type heterocyclic tertiary phosphine ligands and application in Suzuki–Miyaura cross-coupling reactions
  作者：Ehsan Ullah、James McNulty、Christine Kennedy、Al Robertson

  DOI：10.1039/c1ob05426k

  日期：——

  A direct synthesis of conformationally mobile P,O- and P,N-type heterocyclic phosphine ligands is described involving radical-mediated addition of diisobutylphosphine to olefinic-heterocycles. Palladium complexes of the P,N-ligand were determined to be highly active in the Suzuki-Miyaura cross-coupling reactions, including deactivated aryl chlorides.

  描述了构象可移动的P，O-和P，N-型杂环膦配体的直接合成，包括自由基介导的二异丁基膦加成至烯烃-杂环。经测定，P，N-配体的钯配合物在Suzuki-Miyaura交叉偶联反应（包括失活的芳基氯化物）中具有很高的活性。
• ISOQUINOLINE BIARYL COMPOUNDS, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USES THEREOF
  申请人：Ludwig-Maximilians-Universität München

  公开号：EP3653608A1

  公开（公告）日：2020-05-20

  The present invention provides a compound having the formula (I) which is suitable as a tubulin polymerization inhibitor and/or an antimitotic cytotoxin. Thus, it can be employed in the treatment, amelioration or prevention of a disorder selected from a neoplastic disorder, atherosclerosis, psoriasis, restenosis, idiopathic pulmonary fibrosis, scleroderma, wet age-related macular degeneration, and cirrhosis of the liver.

  本发明提供了一种具有化学式(I)的化合物，适用作微管聚合抑制剂和/或抗有丝分裂细胞毒素。因此，它可用于治疗、改善或预防从肿瘤性疾病、动脉粥样硬化、牛皮癣、再狭窄、特发性肺纤维化、硬皮病、湿性年龄相关性黄斑变性和肝硬化中选择的疾病。
• Antimitotic activity of structurally simplified biaryl analogs of the anticancer agents colchicine and combretastatin A4
  作者：James McNulty、Sean van den Berg、Dennis Ma、Daniel Tarade、Seema Joshi、Julia Church、Siyaram Pandey

  DOI：10.1016/j.bmcl.2014.10.090

  日期：2015.1

  Two substituted biaryl analogues of colchicine and combretastatin A4, readily available through a one-step, protecting group free Suzuki-Miyaura reaction were discovered to exhibit anticancer activity while simultaneously being of low cytotoxicity to noncancerous cell lines. The compounds were shown to initiate apoptosis selectively via a mechanism involving inhibition of tubulin polymerization. (C) 2014 Elsevier Ltd. All rights reserved.