4'-dibromomethyl-biphenyl-2-carboxylic acid tert-butyl ester | 901768-33-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-dibromomethyl-biphenyl-2-carboxylic acid tert-butyl ester
• 英文别名: 4'-dibromomethyl-2-(t-butyloxycarbonyl)biphenyl；Tert-butyl 2-[4-(dibromomethyl)phenyl]benzoate
• CAS: 901768-33-0
• 化学式: C₁₈H₁₈Br₂O₂
• 分子量: 426.148
• InChiKey: MSHAAKVSUMAGNO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4’-甲基-[1,1’-联苯]-2-甲酸叔丁酯 在 N-溴代丁二酰亚胺(NBS) 、 偶氮二异丁腈 作用下， 以 四氯化碳 为溶剂， 反应 5.0h， 生成 4'-dibromomethyl-biphenyl-2-carboxylic acid tert-butyl ester 、 4'-溴甲基联苯-2-甲酸叔丁酯
  参考文献：
  名称：

  A Modification to the Synthesis of Telmisartan: An Antihypertensive Drug

  摘要：

  本文介绍了一种高效合成替米沙坦的方法。4,4-二甲基-2-苯基-4,5-二氢恶唑的定向正金属化为钯催化的 3′-（4-溴苄基）-1.H,3′H-2,5′-二芳基偶联提供了关键的有机锌中间体、7′-二甲基-2′-丙基-1H,3′H-2,5′-联苯并[d]咪唑的烷基化提供了关键的有机锌中间体。这种方法克服了以前报道的合成方法的许多缺点。

  DOI：

  10.3184/030823410x12656400473065

文献信息

• A process for producing an aralkyl compound, a dehalogenation method of an aralkyl halide compound and a method for recovering an aralkyl compound
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP1683777A1

  公开（公告）日：2006-07-26

  The present invention provides a process for producing an aralkyl compound which comprises catalytically hydrogenating an aralkyl halide compound in a two-layer solvent system comprising water and water-insoluble organic solvent, a dehalogenation method of aralkyl halide compounds by subjecting to catalytic reduction in a two-layer solvent system comprising water and a water-insoluble organic solvent, and a method for recovering aralkyl compound from waste occurred in production of aralkyl halide compound by halogenation of aralkyl compound using the dehalogenation method.

  本发明提供了一种生产芳基烷基化合物的方法，包括在由水和水不溶性有机溶剂组成的两层溶剂体系中催化氢化芳基卤代烷基化合物的步骤，以及通过在由水和水不溶性有机溶剂组成的两层溶剂体系中进行催化还原来脱卤芳基卤代烷基化合物的去卤素化方法，以及一种通过使用去卤素化方法从生产芳基卤代烷基化合物的废弃物中回收芳基烷基化合物的方法。
• Process for producing an aralkyl compound, a dehalogenation method of an aralkyl halide compound and a method for recovering an aralkyl compound
  申请人：Yamada Seiji

  公开号：US20060167301A1

  公开（公告）日：2006-07-27

  The present invention provides a process for producing an aralkyl compound which comprises catalytically hydrogenating an aralkyl halide compound in a two-layer solvent system comprising water and water-insoluble organic solvent, a dehalogenation method of aralkyl halide compounds by subjecting to catalytic reduction in a two-layer solvent system comprising water and a water-insoluble organic solvent, and a method for recovering aralkyl compound from waste occurred in production of aralkyl halide compound by halogenation of aralkyl compound using the dehalogenation method.

  本发明提供了一种生产芳基化合物的工艺，该工艺包括在由水和水不溶性有机溶剂组成的两层溶剂体系中催化氢化芳基卤化合物，在由水和水不溶性有机溶剂组成的两层溶剂体系中催化还原芳基卤化合物的脱卤方法，以及通过使用脱卤方法卤化芳基化合物从生产芳基卤化合物的废料中回收芳基化合物的方法。
• A Modification to the Synthesis of Telmisartan: An Antihypertensive Drug
  作者：A. Sanjeev Kumar、Samir Ghosh、G. N. Mehta

  DOI：10.3184/030823410x12656400473065

  日期：2010.2

  A highly efficient approach to the synthesis of Telmisartan is described. Directed ortho-metalation of 4,4-dimethyl-2-phenyl-4,5-dihydrooxazole provided the key organozinc intermediate for a palladium catalysed biaryl coupling with 3′-(4-bromobenzyl)-1,7′-dimethyl-2′-propyl-1H,3′H-2,5′-bibenzo[d]imidazole which was obtained from alkylation of 1,7′-dimethyl-2′-propyl-1H,3′H-2,5′-bibenzo[d]imidazole. This methodology overcomes many of the drawbacks associated with previously reported syntheses.

  本文介绍了一种高效合成替米沙坦的方法。4,4-二甲基-2-苯基-4,5-二氢恶唑的定向正金属化为钯催化的 3′-（4-溴苄基）-1.H,3′H-2,5′-二芳基偶联提供了关键的有机锌中间体、7′-二甲基-2′-丙基-1H,3′H-2,5′-联苯并[d]咪唑的烷基化提供了关键的有机锌中间体。这种方法克服了以前报道的合成方法的许多缺点。