苄基-七聚乙二醇-四氢吡喃醚 | 230620-75-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 苄基-七聚乙二醇-四氢吡喃醚
• 英文名称: 1-benzyl-22-(tetrahydropyranyl) heptaethylene glycol
• 英文别名: Benzyl-PEG7-THP；2-[2-[2-[2-[2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]oxane
• CAS: 230620-75-4
• 化学式: C₂₆H₄₄O₉
• 分子量: 500.63
• InChiKey: WMLPAOIUTSGYIB-UHFFFAOYSA-N

物化性质

• 沸点：
  571.3±50.0 °C(Predicted)
• 密度：
  1.10±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  35
• 可旋转键数：
  24
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  83.1
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  苄基-七聚乙二醇-四氢吡喃醚 在 盐酸 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 6.0h， 以100%的产率得到七乙二醇一苯甲醚
  参考文献：
  名称：

  摘要：

  In order to optimize the performance of the AMBRI(TM) biosensor (Nature 1997, 387, 580), a variety of hydrophilic linkers between the hydrophobic bilayer membrane and the gold surface have been synthesized. The principal components are prepared from phytanyl hemisuccinate, which is linked by repeating ethylene glycol or propylene glycol units to a second succinic acid unit. The syntheses of analogous substances in which the ester links are replaced by amide and by ether links are also described.

  DOI：

  10.1071/ch01111
• 作为产物：
  描述：

  三缩四乙二醇 在 sodium hydroxide 、 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 生成 苄基-七聚乙二醇-四氢吡喃醚
  参考文献：
  名称：

  摘要：

  In order to optimize the performance of the AMBRI(TM) biosensor (Nature 1997, 387, 580), a variety of hydrophilic linkers between the hydrophobic bilayer membrane and the gold surface have been synthesized. The principal components are prepared from phytanyl hemisuccinate, which is linked by repeating ethylene glycol or propylene glycol units to a second succinic acid unit. The syntheses of analogous substances in which the ester links are replaced by amide and by ether links are also described.

  DOI：

  10.1071/ch01111

文献信息

• A Convenient Synthetic Route to Differentially Functionalized Long Chain Polyethylene Glycols
  作者：Christopher J. Burns、Leslie D. Field、Kikuko Hashimoto、Brian J. Petteys、Damon D. Ridley、K. R. A. Samankumara Sandanayake

  DOI：10.1080/00397919908086236

  日期：1999.7

  A convenient and efficient synthetic route to differentially functionalized polyethylene glycols (PEGs) starting from cheap commercially available materials is reported. Selectively protected triethylene glycol or tetraethylene glycol have been reacted with a second PEG bearing both a protecting group and a leaving group.