3,3-Dichlor-1-phenyl-4-(p-nitrophenyl)-2-azetidinon | 22086-01-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 3,3-Dichlor-1-phenyl-4-(p-nitrophenyl)-2-azetidinon
• 英文别名: 3,3-Dichloro-4-(4-nitrophenyl)-1-phenyl-azetidin-2-one；3,3-dichloro-4-(4-nitrophenyl)-1-phenylazetidin-2-one
• CAS: 22086-01-7
• 化学式: C₁₅H₁₀Cl₂N₂O₃
• 分子量: 337.162
• InChiKey: DCHZVKFVWLAGQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  66.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对硝基苯甲醛 在 三乙胺 作用下， 以 苯 为溶剂， 反应 3.0h， 生成 3,3-Dichlor-1-phenyl-4-(p-nitrophenyl)-2-azetidinon
  参考文献：
  名称：

  Synthesis and antimicrobial activity of 1,4-diaryl-2-azetidinones

  摘要：

  Cycloaddition of substituted 4,4-benzylidene-anilines to in situ prepared dichloroketenes in the presence of dichloroacetyl chloride and triethylamine affords a variety of 2-azetidinones. All the compounds were characterized by IR and H-1 NMR. Their antimicrobial activity, against Gram(+) and Gram(-) bacteria and fungi, was tested. (C) 2000 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(99)00126-3

文献信息

• SEKIYA M.; MORIMOTO T., CHEM. AND PHARM BULL. <CPBT-AL>, 1975, 23, NO 10, 2353-2357
  作者：SEKIYA M.、 MORIMOTO T.

  DOI：——

  日期：——
• MORIMOTO T.; SEKIYA M., CHEM. AND PHARM. BULL. <CPBT-AL>, 1976, 24, NO 8, 1935-1938
  作者：MORIMOTO T.、 SEKIYA M.

  DOI：——

  日期：——
• Synthesis and antimicrobial activity of 1,4-diaryl-2-azetidinones
  作者：Vıldan Güner、Süleyman Yıldırır、Berrın Özçelık、Ufuk Abbasoğlu

  DOI：10.1016/s0014-827x(99)00126-3

  日期：2000.2

  Cycloaddition of substituted 4,4-benzylidene-anilines to in situ prepared dichloroketenes in the presence of dichloroacetyl chloride and triethylamine affords a variety of 2-azetidinones. All the compounds were characterized by IR and H-1 NMR. Their antimicrobial activity, against Gram(+) and Gram(-) bacteria and fungi, was tested. (C) 2000 Elsevier Science S.A. All rights reserved.