5-(4-Bromophenyl)-2,8-dimethylnona-2,7-dien-5-ol | 1448993-52-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(4-Bromophenyl)-2,8-dimethylnona-2,7-dien-5-ol
• 英文别名: 5-(4-bromophenyl)-2,8-dimethylnona-2,7-dien-5-ol
• CAS: 1448993-52-9
• 化学式: C₁₇H₂₃BrO
• 分子量: 323.273
• InChiKey: LFVHWFVWQYDIOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-溴-3-甲基-2-丁烯 以 四氢呋喃 为溶剂， 反应 21.0h， 生成 5-(4-Bromophenyl)-2,8-dimethylnona-2,7-dien-5-ol
  参考文献：
  名称：

  α-Regioselective construction of gem-bisprenyl structures via zinc-mediated prenylation of esters in THF

  摘要：

  The in situ generated prenylzinc reagent from the reaction of zinc with prenyl bromide has been shown to undergo a new type of alpha-regioselective addition reaction with a wide range of esters that affords gem-bisprenyl structures. The reaction proceeds under mild conditions to provide alpha,alpha'-adducts with complete alpha-regioselectivity. A mechanism with the consideration of the steric factors is proposed to account for the regioselective results. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.07.008

文献信息

• α-Regioselective construction of gem-bisprenyl structures via zinc-mediated prenylation of esters in THF
  作者：Li-Ming Zhao、Li-Jing Wan、Shu-Qing Zhang、Rui Sun、Feng-Yan Ma

  DOI：10.1016/j.tet.2013.07.008

  日期：2013.9

  The in situ generated prenylzinc reagent from the reaction of zinc with prenyl bromide has been shown to undergo a new type of alpha-regioselective addition reaction with a wide range of esters that affords gem-bisprenyl structures. The reaction proceeds under mild conditions to provide alpha,alpha'-adducts with complete alpha-regioselectivity. A mechanism with the consideration of the steric factors is proposed to account for the regioselective results. (C) 2013 Elsevier Ltd. All rights reserved.