(1S,10R,11R)-4-methoxy-18-methyl-6-oxa-18-azapentacyclo[8.5.3.01,11.02,8.05,7]octadeca-2,4,7-trien-14-one

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: (1S,10R,11R)-4-methoxy-18-methyl-6-oxa-18-azapentacyclo[8.5.3.01,11.02,8.05,7]octadeca-2,4,7-trien-14-one
• 化学式: C₁₈H₂₁NO₃
• 分子量: 299.4
• InChiKey: UGIDQUJLGNGHIC-WRSAYESZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  42.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• EP3193873A1
  申请人：——

  公开号：EP3193873A1

  公开（公告）日：2017-07-26
• EP3749332A1
  申请人：——

  公开号：EP3749332A1

  公开（公告）日：2020-12-16
• [EN] ORALLY ADMINISTRABLE COMPOSITIONS AND METHODS OF DETERRING ABUSE BY INTRANASAL ADMINISTRATION<br/>[FR] COMPOSITION POUR ADMINISTRATION ORALE ET PROCÉDÉS DE PRÉVENTION DES ADDICTIONS PAR ADMINISTRATION INTRANASALE
  申请人：INSPIRION DELIVERY TECHNOLOGIES LLC

  公开号：WO2016043698A1

  公开（公告）日：2016-03-24

  The present invention provides an orally administrable pharmaceutical composition comprising a drug and one or more pharmaceutically acceptable excipients in an amount sufficient to deter abuse by nasal insufflation, wherein the pharmaceutical composition is configured such that when the pharmaceutical composition is intranasally administered in physically compromised form to a subject, the Cmax and/or AUG of the drug achieved after a time period is lower than the Cmax and/or AUG of the drug achieved after intranasal administration of a physically compromised form of an orally bioequivalent composition not containing one or more pharmaceutically acceptable excipients in an amount sufficient to deter abuse by nasal insufflation.
• [EN] TREATMENT OF OPIOID TOLERANCE<br/>[FR] TRAITEMENT DE LA TOLÉRANCE AUX OPIOÏDES
  申请人：UNIV DUNDEE

  公开号：WO2017199014A1

  公开（公告）日：2017-11-23

  The present invention relates to the use of c-Src inhibitors for the mitigation of side-effects associated with opioid analgesia and in particular for the mitigation of opioid tolerance in human and veterinary medicine.
• [EN] COMPOSITIONS AND THEIR USE IN THE TREATMENT OF ENDOMETRIOSIS AND PAIN<br/>[FR] COMPOSITIONS ET LEUR UTILISATION DANS LE TRAITEMENT DE L'ENDOMÉTRIOSE ET DE LA DOULEUR
  申请人：RR MEDSCIENCES PTY LTD

  公开号：WO2019153051A1

  公开（公告）日：2019-08-15

  Disclosed are compositions useful in the treatment or prevention of endometriosis and pain. Also disclosed are methods for the treatment and/or prevention of endometriosis and pain.