5-[4-(benzylamino)phthalazin-1-yl]-N-tert-butyl-2-methylbenzenesulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-[4-(benzylamino)phthalazin-1-yl]-N-tert-butyl-2-methylbenzenesulfonamide
• 化学式: C₂₆H₂₈N₄O₂S
• mdl: MFCD02242649
• 分子量: 460.6
• InChiKey: NKQNZMPVGGAOND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  92.4
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] 3-(PHTHALAZIN-1-YL)BENZENESULFONAMIDE-BASED SLC16A3 INHIBITORS AND THEIR THERAPEUTIC USE<br/>[FR] INHIBITEURS DE SLC16A3 À BASE DE 3-(PHTALAZIN-1-YL) BENZÈNESULFONAMIDE ET LEUR UTILISATION THÉRAPEUTIQUE
  申请人：[en]CEMM - FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GMBH

  公开号：WO2022243574A1

  公开（公告）日：2022-11-24

  The present invention provides 3-(phthalazin-1-yl)benzenesulfonamide-based compounds of formula (I), Formula (I) and pharmaceutically acceptable salts thereof, which have been found to be advantageously potent and selective inhibitors of SLC16A3, as well as their use in the treatment or prevention of SLC16A3-associated diseases/disorders such as cancer.