Benzyl-(1-propyl-pentyl)-amine | 90496-20-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzyl-(1-propyl-pentyl)-amine
• 英文别名: N-benzyloctan-4-amine
• CAS: 90496-20-1
• 化学式: C₁₅H₂₅N
• 分子量: 219.37
• InChiKey: XCLYGOINUXOKPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-butylidenebenzylamine 以61%的产率得到
  参考文献：
  名称：

  Katritzky Alan R., Hong Qingmei, Yang Zhijun, J. Org. Chem., 59 (1994) N 26, S 7947- 7948

  摘要：

  DOI：

文献信息

• Addition of boron trifluoride complexes of organocopper reagentsto aldimines containing α-hydrogens
  作者：Makoto Wada、Yōji Sakurai、Kin-ya Akiba

  DOI：10.1016/s0040-4039(01)80106-4

  日期：1984.1

  RCu · BF3, generated in situ from Grignard reagents, CuI, and BF3 · OEt2, added to aldimines containing α-hydrogens to afford secondary amines in good yields. Boron trifluoride complex of dialkylcuprate gave essentially the same result with wider application.

  由Grignard试剂CuI和BF 3 ·OEt 2原位生成的RCu·BF 3加入到含有α氢的醛亚胺中，以高收率得到仲胺。三烷基硼酸酯的三氟化硼配合物在更广泛的应用中获得了基本相同的结果。
• Preparations of Secondary Amines and .beta.-Amino Esters via Additions of Grignard and Reformatsky Reagents to Imines and by One-Pot Reactions of Primary Amines, Aldehydes, and Grignards
  作者：Alan R. Katritzky、Qingmei Hong、Zhijun Yang

  DOI：10.1021/jo00116a027

  日期：1995.6

  Additions oi. Grignard and Reformatsky reagents to imines in the presence of 1-(trimethylsilyl)benzotriazole afforded in good yields the corresponding secondary amines and p-amino esters. The procedure is general as imines containing hydrogens a to both carbon and nitrogen can be employed. Extensions of this method to include imines containing other Lewis basic centers, e.g., those derived from furan-, thiophene-, indole-, and p-methoxybenzenecarboxaldehyde, have been successful in avoiding the potential complications which could result from the use of a Lewis acid as the activating : species. The imines need not be isolated, and a one-pot method for the synthesis of secondary amines from aldehydes, primary amines, and Grignard reagents is described.
• Katritzky Alan R., Hong Qingmei, Yang Zhijun, J. Org. Chem, 60 (1995) N 11, S 3405-3408
  作者：Katritzky Alan R., Hong Qingmei, Yang Zhijun

  DOI：——

  日期：——
• WADA, MAKOTO;SAKURAI, YOJI;AKIBA, KIN-YA, TETRAHEDRON LETT., 1984, 25, N 10, 1079-1082
  作者：WADA, MAKOTO、SAKURAI, YOJI、AKIBA, KIN-YA

  DOI：——

  日期：——
• 1-(Trimethylsilyl)benzotriazole-Assisted Addition of Grignard Reagents to Imines: A Versatile Approach to Aliphatic Secondary Amines
  作者：Alan R. Katritzky、Qingmei Hong、Zhijun Yang

  DOI：10.1021/jo00105a003

  日期：1994.12

  1-(Trimethylsilyl)benzotriazole-assisted Grignard addition to imines is described.