3-(3-Methyl-thiophen-2-yl)-propan-1-ol | 1000518-83-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 3-(3-Methyl-thiophen-2-yl)-propan-1-ol
• 英文别名: 3-Methylthiolpropanol；3-(3-methylthiophen-2-yl)propan-1-ol
• CAS: 1000518-83-1
• 化学式: C₈H₁₂OS
• 分子量: 156.249
• InChiKey: BJFLSXVTUNGWQH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  48.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(3-Methyl-thiophen-2-yl)-propan-1-ol 在 咪唑 、 盐酸 、 甲醇 、 正丁基锂 、 碘 、 potassium carbonate 、 三苯基膦 作用下， 以 甲醇 、 甲苯 为溶剂， 生成 Carbamic acid (6Z,11Z)-(1S,2S,3R,4S,8S,9S,10S)-3,9-dihydroxy-2,4,6,8,10-pentamethyl-1-((Z)-(S)-1-methyl-penta-2,4-dienyl)-14-(3-methyl-thiophen-2-yl)-tetradeca-6,11-dienyl ester
  参考文献：
  名称：

  Design, synthesis and cytotoxicity of 7-deoxy aryl discodermolide analogues

  摘要：

  A series of 7-deoxy discodermolide analogues in which the lactone fragment 'C' was replaced by aryl substituents were designed, synthesized, and evaluated for cytotoxicity. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.01.102
• 作为产物：
  描述：

  magnesium,3-methyl-2H-thiophen-2-ide,bromide 在 9-borabicyclo[3.3.1]nonane dimer 作用下， 生成 3-(3-Methyl-thiophen-2-yl)-propan-1-ol
  参考文献：
  名称：

  Design, synthesis and cytotoxicity of 7-deoxy aryl discodermolide analogues

  摘要：

  A series of 7-deoxy discodermolide analogues in which the lactone fragment 'C' was replaced by aryl substituents were designed, synthesized, and evaluated for cytotoxicity. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.01.102

文献信息

• [EN] QUINOLINECARBOXAMIDES AS ANTIVIRAL AGENTS<br/>[FR] QUINOLINECARBOXAMIDES AGENTS ANTIVIRAUX
  申请人：UPJOHN CO

  公开号：WO2000040561A1

  公开（公告）日：2000-07-13

  The present invention provides a compound of formula (I) which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.

  本发明提供了一种化合物，其化学式为(I)，可用作抗病毒剂，特别是用于对抗疱疹病毒家族的病毒。
• Quinolinecarboxamides as antiviral agents
  申请人：Pharmacia & Upjohn Company

  公开号：US06248739B1

  公开（公告）日：2001-06-19

  The present invention provides a compound of formula I which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.

  本发明提供了一种I式化合物，其作为抗病毒剂特别是作为针对疱疹病毒家族的药剂使用。
• Prevention of lactic acid bacteria spoilage of beer through use of bacteriocin-containing fermented wort
  申请人：Kraft Foods Holdings, Inc.

  公开号：US20020192331A1

  公开（公告）日：2002-12-19

  The present invention provides alcoholic beverages which are stabilized against the growth of microorganisms whose growth may cause deterioration of the characteristics of the alcoholic beverages. The stabilized beverages are attained by utilization of a composition which includes a nisin-producing culture and a nutritional supplement in the process of making the alcoholic beverage. The composition of this invention includes nisin at a level effective for inhibiting growth of the spoilage-causing microorganisms, particularly, hardier strains of such microorganisms that may exhibit resistance to lower levels of nisin. The composition is prepared by adding to an aqueous medium, such as wort obtained in the process of making the alcoholic beverage, a nutritional supplement of a type and in an amount that is effective for increasing the yield of nisin, adjusting the pH of the wort to about 6.5, pasteurizing and cooling, inoculating the medium with a culture of nisin-producing microorganism, and fermenting the medium with a nisin-producing culture.

  本发明提供的含酒精饮料可以防止微生物的生长，因为微生物的生长可能会导致含酒精饮料的特性变差。在制造酒精饮料的过程中，通过使用一种包括产尼生素培养物和营养补充剂的组合物，可以获得稳定的饮料。本发明的组合物中的尼生素能有效抑制引起腐败的微生物的生长，特别是对较低浓度的尼生素有抗性的较硬的微生物菌株。本发明组合物的制备方法是：向水介质（例如在酒精饮料制造过程中获得的麦汁）中加入一种营养补充剂，该营养补充剂的类型和用量对提高尼生素的产量有效；将麦汁的 pH 值调节到 6.5 左右；巴氏杀菌并冷却；用产生尼生素的微生物培养物接种介质；用产生尼生素的培养物发酵介质。
• QUINOLINECARBOXAMIDES AS ANTIVIRAL AGENTS
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：EP1140850A1

  公开（公告）日：2001-10-10
• US6248739B1
  申请人：——

  公开号：US6248739B1

  公开（公告）日：2001-06-19