2-thiophen-2-yl-N-[10-[(2-thiophen-2-ylacetyl)amino]decyl]acetamide | 1160003-26-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 2-thiophen-2-yl-N-[10-[(2-thiophen-2-ylacetyl)amino]decyl]acetamide
• CAS: 1160003-26-8
• 化学式: C₂₂H₃₂N₂O₂S₂
• 分子量: 420.64
• InChiKey: PREHJGGKKDAUJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  28
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  115
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-噻吩乙酰氯 、 癸二胺 以 四氢呋喃 为溶剂， 以77%的产率得到2-thiophen-2-yl-N-[10-[(2-thiophen-2-ylacetyl)amino]decyl]acetamide
  参考文献：
  名称：

  Synthesis and Biological Evaluation of N,N′-di(thiopheneacetyl)diamines Series as Antitubercular Agents

  摘要：

  The series of new N,N'-di(thiopheneacetyl)diamines derivatives, 8-17, were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis(TB), and the activity expressed as the minimum inhibitory concentration (MIC) in g/mL. Compound 13 was the only one determined to be active and exhibited a MIC 50 g/mL, indicating that the alkyl chain-length of the diamines is critical for biological activity. This class of compound has not been evaluated before, and it could be a good starting point to find new lead compounds in the fight against multi-drug resistant TB.

  DOI：

  10.1080/10426500802049803