2-thiophen-2-yl-N-[10-[(2-thiophen-2-ylacetyl)amino]decyl]acetamide | 1160003-26-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 2-thiophen-2-yl-N-[10-[(2-thiophen-2-ylacetyl)amino]decyl]acetamide
• CAS: 1160003-26-8
• 化学式: C₂₂H₃₂N₂O₂S₂
• 分子量: 420.64
• InChiKey: PREHJGGKKDAUJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  28
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  115
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-噻吩乙酰氯 、 癸二胺 以 四氢呋喃 为溶剂， 以77%的产率得到2-thiophen-2-yl-N-[10-[(2-thiophen-2-ylacetyl)amino]decyl]acetamide
  参考文献：
  名称：

  Synthesis and Biological Evaluation of N,N′-di(thiopheneacetyl)diamines Series as Antitubercular Agents

  摘要：

  The series of new N,N'-di(thiopheneacetyl)diamines derivatives, 8-17, were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis(TB), and the activity expressed as the minimum inhibitory concentration (MIC) in g/mL. Compound 13 was the only one determined to be active and exhibited a MIC 50 g/mL, indicating that the alkyl chain-length of the diamines is critical for biological activity. This class of compound has not been evaluated before, and it could be a good starting point to find new lead compounds in the fight against multi-drug resistant TB.

  DOI：

  10.1080/10426500802049803

文献信息

• Synthesis and Biological Evaluation of N,N′-di(thiopheneacetyl)diamines Series as Antitubercular Agents
  作者：Marcus Vinícius Nora de Souza、Maria Cristina Silva Lourenço、Mônica Amado Peralta、Raoni Schroeder Borges Gonçalves、Thais Cristina Mendonça Nogueira、Camilo Henrique da Silva Lima、Marcelle de Lima Ferreira、Emerson Teixeira da Silva

  DOI：10.1080/10426500802049803

  日期：2008.11.7

  The series of new N,N'-di(thiopheneacetyl)diamines derivatives, 8-17, were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis(TB), and the activity expressed as the minimum inhibitory concentration (MIC) in g/mL. Compound 13 was the only one determined to be active and exhibited a MIC 50 g/mL, indicating that the alkyl chain-length of the diamines is critical for biological activity. This class of compound has not been evaluated before, and it could be a good starting point to find new lead compounds in the fight against multi-drug resistant TB.