2-amino-3-methylthio-4-picoline | 179554-97-3

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-amino-3-methylthio-4-picoline
• 英文别名: 4-methyl-3-(methylthio)-2-Pyridinamine；4-methyl-3-methylsulfanylpyridin-2-amine
• CAS: 179554-97-3
• 化学式: C₇H₁₀N₂S
• 分子量: 154.236
• InChiKey: YVBYIERVWATQSM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  64.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,2-Dimethyl-N-<4-methyl-3-(methylthio)-2-pyridinyl>propanamide 在 乙醚 、 Sodium sulfate-III 作用下， 以 盐酸 、 水 为溶剂， 反应 10.0h， 以to afford the title compound (150 mg)的产率得到2-amino-3-methylthio-4-picoline
  参考文献：
  名称：

  Substituted 2-aminopyridines as inhibitors of nitric oxide synthase

  摘要：

  化合物公式为（I）的2-氨基吡啶衍生物及其药学上可接受的盐，在治疗一氧化氮合酶介导的疾病和紊乱方面已经被发现有用。##STR1##

  公开号：

  US05972975A1

文献信息

• [EN] BIPYRIDYL AMINES AND ETHERS AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5<br/>[FR] AMINES ET ETHERS DE BIPYRIDYLE UTILISES COMME MODULATEURS DU RECEPTEUR 5 METABOTROPIQUE AU GLUTAMATE
  申请人：MERCK & CO INC

  公开号：WO2005021529A1

  公开（公告）日：2005-03-10

  The present invention is directed to novel bipyridyl amine and ether compounds such as those of Formula (I): (I) (where R?1#191, R?2#191, R?3#191, X and Y are as defined herein) which are mGluR5 modulators useful in the treatment or prevention of diseases and conditions in which mGluR5 is involved, including but not limited to psychiatric and mood disorders such as schizophrenia, anxiety, depression, bipolar disorders, and panic, as well as in the treatment of pain, Parkinson’s disease, cognitive dysfunction, epilepsy, circadian rhythm and sleep disorders, such as shift-work induced sleep disorder and jet-lag, drug addiction, drug abuse, drug withdrawal, obesity and other diseases. The invention is also directed to pharmaceutical compositions comprising these compounds. This invention further provides a method of treatment of these disorders and conditions by the administration of an effective amount of these novel bipyridyl amine and/or ether compounds and/or compositions containing these compounds.

  本发明涉及一种新型的双吡啶基胺和醚化合物，例如式(I)中的化合物：（I）（其中R?1#191，R?2#191，R?3#191，X和Y的定义如本文所述），这些化合物是mGluR5调节剂，可用于治疗或预防涉及mGluR5的疾病和症状，包括但不限于精神和情绪障碍，如精神分裂症、焦虑、抑郁症、双相情感障碍和恐慌，以及用于疼痛、帕金森病、认知功能障碍、癫痫、昼夜节律和睡眠障碍，如倒班工作引起的睡眠障碍和时差反应，药物成瘾、药物滥用、戒断综合征、肥胖症和其他疾病的治疗。本发明还涉及包含这些化合物的药物组合物。本发明还提供了一种通过给予这些新型双吡啶基胺和/或醚化合物和/或含有这些化合物的组合物的有效量来治疗这些障碍和症状的方法。
• Bipyridyl amines and ethers as modulators of metabotropic glutamate receptor-5
  申请人：Kamenecka M. Theodore

  公开号：US20070027321A1

  公开（公告）日：2007-02-01

  The present invention is directed to novel bipyridyl amine and ether compounds such as those of Formula (I): (I) (where R?1#191, R?2#191, R?3#191, X and Y are as defined herein) which are mGluR5 modulators useful in the treatment or prevention of diseases and conditions in which mGluR5 is involved, including but not limited to psychiatric and mood disorders such as schizophrenia, anxiety, depression, bipolar disorders, and panic, as well as in the treatment of pain, Parkinson's disease, cognitive dysfunction, epilepsy, circadian rhythm and sleep disorders, such as shift-work induced sleep disorder and jet-lag, drug addiction, drug abuse, drug withdrawal, obesity and other diseases. The invention is also directed to pharmaceutical compositions comprising these compounds. This invention further provides a method of treatment of these disorders and conditions by the administration of an effective amount of these novel bipyridyl amine and/or ether compounds and/or compositions containing these compounds.

  本发明涉及新型的联吡啶胺和醚化合物，例如公式(I)中的化合物：(I) (其中R?1#191，R?2#191，R?3#191，X和Y如本文所定义)，这些化合物是mGluR5调节剂，可用于治疗或预防涉及mGluR5的疾病和病况，包括但不限于精神和情绪障碍，如精神分裂症、焦虑、抑郁、双相障碍和惊恐，以及治疗疼痛、帕金森病、认知功能障碍、癫痫、昼夜节律和睡眠障碍，如倒班工作引起的睡眠障碍和时差反应、药物成瘾、药物滥用、戒断综合征、肥胖症和其他疾病。本发明还涉及包含这些化合物的药物组合物。本发明还提供了通过给予这些新型联吡啶胺和/或醚化合物和/或含有这些化合物的组合物的有效量来治疗这些障碍和病况的方法。
• BIPYRIDYL AMINES AND ETHERS AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5
  申请人：Merck & Co., Inc.

  公开号：EP1664018A1

  公开（公告）日：2006-06-07
• US5972975A
  申请人：——

  公开号：US5972975A

  公开（公告）日：1999-10-26
• [EN] SUBSTITUTED 2-AMINOPYRIDINES AS INHIBITORS OF NITRIC OXIDE SYNTHASE<br/>[FR] 2-AMINOPYRIDINES SUBSTITUEES UTILISEES COMME INHIBITEURS DE SYNTHASE D'OXYDE D'AZOTE
  申请人：MERCK & CO., INC.

  公开号：WO1996018616A1

  公开（公告）日：1996-06-20

  (EN) Substituted 2-aminopyridine compounds and pharmaceutically acceptable salts which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders.(FR) Composés de 2-aminopyridine substituée et leurs sels viables sur le plan pharmaceutique pouvant être utilisés dans le traitement de maladies et de troubles dus à la synthase d'oxyde d'azote.