Methyl 2-(1-benzyl-2-methylindol-4-yl)oxy-2,3,3,3-tetrafluoropropanoate | 1208132-03-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 2-(1-benzyl-2-methylindol-4-yl)oxy-2,3,3,3-tetrafluoropropanoate
• CAS: 1208132-03-9
• 化学式: C₂₀H₁₇F₄NO₃
• 分子量: 395.353
• InChiKey: SOUHRPLTYIDUFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  40.5
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2-溴-2,3,3,3-四氟丙酸甲酯 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 18.5h， 以17%的产率得到Methyl 2-(1-benzyl-2-methylindol-4-yl)oxy-2,3,3,3-tetrafluoropropanoate
  参考文献：
  名称：

  WO2007/56275

  摘要：

  公开号：

文献信息

• Multivalent indole compounds and use thereof as phospholipase-A2 inhibitors
  申请人：Chang Han-Ting

  公开号：US20070135385A1

  公开（公告）日：2007-06-14

  Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject.

  吲哚和与吲哚相关的化合物、组合物以及方法被披露。发明中的这些化合物作为磷脂酶抑制剂非常有用。发明中的这些化合物和组合物用于治疗动物受试者中的磷脂酶相关状况，例如胰岛素相关、体重相关和/或胆固醇相关状况。
• Phospholipase inhibitors, including multi-valent phospholipase inhibitors, and use thereof, including as lumen-localized phospholipase inhibitors
  申请人：Chang Han-Ting

  公开号：US20070135383A1

  公开（公告）日：2007-06-14

  The present invention provides methods and compositions for the treatment of phospholipase-related conditions. In particular, the invention provides a method of treating insulin-related, weight-related conditions and/or cholesterol-related conditions in an animal subject. The method generally involves the administration of a non-absorbed and/or effluxed phospholipase A2 inhibitor that is localized in a gastrointestinal lumen.

  本发明提供了治疗磷脂酶相关疾病的方法和组合物。具体地，本发明提供了一种用于治疗动物主体中的胰岛素相关、体重相关和/或胆固醇相关疾病的方法。该方法通常涉及在胃肠道腔中定位的非吸收和/或外流的磷脂酶A2抑制剂的给药。
• INDOLE COMPOUNDS HAVING C4-AMIDE SUBSTITUENTS AND USE THEREOF AS PHOSPHOLIPASE-A2 INHIBITORS
  申请人：Chang Han-Ting

  公开号：US20090306171A1

  公开（公告）日：2009-12-10

  Indole and indole-related compounds according to the formula (I) or (II) optionally having additional heteroatoms, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject. Formula (I), formula (II). R 4 being a moiety represented by formula (C4-II-C), R 3 being a moiety represented by formula (C3-I or C3-II).

  本发明揭示了具有公式（I）或（II）的吲哚和吲哚相关化合物，可选择具有额外杂原子，以及组合物和方法。本发明的化合物可用作磷脂酶抑制剂。本发明的化合物和组合物可用于治疗磷脂酶相关疾病，例如动物体内的胰岛素相关、体重相关和/或胆固醇相关疾病。其中，公式（I）和公式（II）中，R4是由公式（C4-II-C）表示的基团，R3是由公式（C3-I或C3-II）表示的基团。
• US7666898B2
  申请人：——

  公开号：US7666898B2

  公开（公告）日：2010-02-23
• [EN] INDOLE COMPOUNDS HAVING C4-AMIDE SUBSTITUENTS AND USE THEREOF AS PHOSPHOLIPASE-A2 INHIBITORS<br/>[FR] COMPOSES D'INDOLE PRESENTANT DES SUBSTITUANTS AMIDES C4 ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE PHOSPHOLIPASES A2
  申请人：ILYPSA INC

  公开号：WO2007056275A2

  公开（公告）日：2007-05-18

  [EN] Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject.
  [FR] L'invention concerne de l'indole et des composés apparentés à l'indole, des compositions et des méthodes. Les composés de l'invention sont utiles en tant qu'inhibiteurs de phospholipases. Les composés et compositions de l'invention sont utiles pour le traitement d'états liés aux phospholipases, tels que les états liés à l'insuline, liés au poids et/ou liés au cholestérol chez un sujet animal.