2-(1,3-benzoxazol-2-ylamino)-4-phenyl-4,6,7,8-tetrahydro-1H-quinazolin-5-one | 669718-41-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(1,3-benzoxazol-2-ylamino)-4-phenyl-4,6,7,8-tetrahydro-1H-quinazolin-5-one
• CAS: 669718-41-6
• 化学式: C₂₁H₁₈N₄O₂
• 分子量: 358.4
• InChiKey: NUFKVTASOYCYME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  79.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-1,3-苯并噁唑-2-胍 、 1,3-环己二酮 、 苯甲醛 以 1,4-二氧六环 为溶剂， 反应 3.0h， 以68%的产率得到2-(1,3-benzoxazol-2-ylamino)-4-phenyl-4,6,7,8-tetrahydro-1H-quinazolin-5-one
  参考文献：
  名称：

  杂芳基胍与醛（酮）和二羰基化合物的三组分缩合

  摘要：

  DOI：

  10.1007/s10593-006-0245-5

文献信息

• [EN] GALACTOKINASE INHIBITORS FOR THE TREATMENT AND PREVENTION OF ASSOCIATED DISEASES AND DISORDERS<br/>[FR] INHIBITEURS DE GALACTOKINASE POUR LE TRAITEMENT ET LA PRÉVENTION DE MALADIES ET DE TROUBLES ASSOCIÉS
  申请人：US HEALTH

  公开号：WO2013043192A1

  公开（公告）日：2013-03-28

  Disclosed are inhibitors of human galactokinase of formula (1) that are useful in treating or preventing a galactokinase mediated disease or disorder, e.g., galactosemia. Also disclosed are a composition comprising a pharmaceutically acceptable carrier and at least one inhibitor of the invention, and a method of treating or preventing such disease or disorder in a mammal. Formula (I)

  本发明涉及一种公开的人类半乳糖激酶抑制剂，其化学式为（1），可用于治疗或预防半乳糖激酶介导的疾病或疾病，例如半乳糖血症。还公开了一种包含药学上可接受的载体和本发明中至少一种抑制剂的组合物，以及一种在哺乳动物中治疗或预防该类疾病或疾病的方法。化学式（I）
• Galactokinase inhibitors for the treatment and prevention of associated diseases and disorders
  申请人：The United States of America, as represented by the Secretary, Department of Health and Human Services

  公开号：US10471061B2

  公开（公告）日：2019-11-12

  Disclosed are inhibitors of human galactokinase of formula (I) that are useful in treating or preventing a galactokinase mediated disease or disorder, e.g., galactosemia. Also disclosed are a composition comprising a pharmaceutically acceptable carrier and at least one inhibitor of the invention, and a method of treating or preventing such disease or disorder in a mammal. Formula (I).

  本发明公开了式(I)的人半乳糖激酶抑制剂，可用于治疗或预防半乳糖激酶介导的疾病或紊乱，如半乳糖血症。还公开了一种包含药学上可接受的载体和至少一种本发明抑制剂的组合物，以及一种治疗或预防哺乳动物中此类疾病或紊乱的方法。式 (I).
• Three-component condensation of hetarylguanidines with aldehydes (ketones) and dicarbonyl compounds
  作者：A. Yu. Potapov、Kh. S. Shikhaliev、D. V. Krylsky、M. Yu. Krisin

  DOI：10.1007/s10593-006-0245-5

  日期：2006.10
• GALACTOKINASE INHIBITORS FOR THE TREATMENT AND PREVENTION OF ASSOCIATED DISEASES AND DISORDERS
  申请人：Boxer Matthew B.

  公开号：US20140288100A1

  公开（公告）日：2014-09-25

  Disclosed are inhibitors of human galactokinase of formula (1) that are useful in treating or preventing a galactokinase mediated disease or disorder, e.g., galactosemia. Also disclosed are a composition comprising a pharmaceutically acceptable carrier and at least one inhibitor of the invention, and a method of treating or preventing such disease or disorder in a mammal. Formula (I)
• US9447087B2
  申请人：——

  公开号：US9447087B2

  公开（公告）日：2016-09-20