2,6-difluoro-4'-methoxy-3-nitro-1,1'-biphenyl | 1361405-10-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6-difluoro-4'-methoxy-3-nitro-1,1'-biphenyl
• 英文别名: 1,3-Difluoro-2-(4-methoxyphenyl)-4-nitrobenzene
• CAS: 1361405-10-8
• 化学式: C₁₃H₉F₂NO₃
• 分子量: 265.216
• InChiKey: CVXLPIXVVAODFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-碘苯甲醚 、 2,4-二氟硝基苯 在 palladium diacetate 、 三苯基膦 、 silver carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以78%的产率得到2,6-difluoro-4'-methoxy-3-nitro-1,1'-biphenyl
  参考文献：
  名称：

  Pd-Catalyzed Direct Arylation of Polyfluoroarenes on Water under Mild Conditions Using PPh₃ Ligand

  摘要：

  We report a Pd-catalyzed direct arylation of polyfluoroarenes with aryl iodides. The advantages of this reaction are its high reaction efficiency, excellent functional group compatibility, mild reaction conditions (70 degrees C), inexpensive PPh3 ligand, and use of pure water as reaction medium. The usefulness of this reaction has also been demonstrated by rapid preparation of highly functionalized polyfluoroarenes via iterative Pd-catalyzed C-H bond functionalization.

  DOI：

  10.1021/jo300036d

文献信息

• ORGANOZINC COMPOSITION
  申请人：Ludwig-Maximilians-Universität München

  公开号：EP3168224A1

  公开（公告）日：2017-05-17

  The present invention relates to compositions containing a zinc complex wherein a zinc atom carries two amide ligands, a lithium salt and a defined solvent. The compositions are stable and show high activity as reactants for metalation reactions, and thus provide a valuable tool in organic synthesis. Moreover, the invention relates to processes for the preparation of the compositions and to synthetic procedures using them.

  本发明涉及一种含有锌络合物的组合物，其中一个锌原子携带两个酰胺配体、一种锂盐和一种确定的溶剂。这种复合物稳定，作为金属化反应的反应物具有高活性，因此为有机合成提供了有价值的工具。此外，本发明还涉及组合物的制备工艺和使用组合物的合成程序。
• Pd-Catalyzed Direct Arylation of Polyfluoroarenes on Water under Mild Conditions Using PPh₃ Ligand
  作者：Fei Chen、Qiao-Qiao Min、Xingang Zhang

  DOI：10.1021/jo300036d

  日期：2012.3.16

  We report a Pd-catalyzed direct arylation of polyfluoroarenes with aryl iodides. The advantages of this reaction are its high reaction efficiency, excellent functional group compatibility, mild reaction conditions (70 degrees C), inexpensive PPh3 ligand, and use of pure water as reaction medium. The usefulness of this reaction has also been demonstrated by rapid preparation of highly functionalized polyfluoroarenes via iterative Pd-catalyzed C-H bond functionalization.