N-Isopropyl-6-hydroxypyridine-2-carboxamide | 149744-23-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-Isopropyl-6-hydroxypyridine-2-carboxamide
• 英文别名: 6-hydroxy-N-(propan-2-yl)pyridine-2-carboxamide；6-oxo-N-propan-2-yl-1H-pyridine-2-carboxamide
• CAS: 149744-23-0
• 化学式: C₉H₁₂N₂O₂
• 分子量: 180.206
• InChiKey: YKTUNWYSSHLMKT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  甲基磺酰氯 、 N-Isopropyl-6-hydroxypyridine-2-carboxamide 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 N-Isopropyl-6-methanesulfonyloxypyridine-2-carboxamide
  参考文献：
  名称：

  Synthesis and Insecticidal Activity of Novel Pyridine Methanesulfonates

  摘要：

  A model has been developed which has led to the design and synthesis of novel 6-methanesulfonyloxypyridine-2-carboxamides with insecticidal activity, low mammalian toxicity and safety to aquatic organisms. The amides formed from amines with alpha branching (e.g. isopropyl and sec-butyl) demonstrated the highest level of activity. Rice nursery box field test results on laboratory raised insects gave insufficient control of the entire Japanese hopper spectrum to warrant further development of these compounds.

  DOI：

  10.1002/(sici)1096-9063(199708)50:4<319::aid-ps595>3.0.co;2-e
• 作为产物：
  描述：

  6-羟基吡啶-2-羧酸 以 四氢呋喃 为溶剂， 反应 1.5h， 生成 N-Isopropyl-6-hydroxypyridine-2-carboxamide
  参考文献：
  名称：

  Synthesis and Insecticidal Activity of Novel Pyridine Methanesulfonates

  摘要：

  A model has been developed which has led to the design and synthesis of novel 6-methanesulfonyloxypyridine-2-carboxamides with insecticidal activity, low mammalian toxicity and safety to aquatic organisms. The amides formed from amines with alpha branching (e.g. isopropyl and sec-butyl) demonstrated the highest level of activity. Rice nursery box field test results on laboratory raised insects gave insufficient control of the entire Japanese hopper spectrum to warrant further development of these compounds.

  DOI：

  10.1002/(sici)1096-9063(199708)50:4<319::aid-ps595>3.0.co;2-e

文献信息

• Inhibitors of cysteine proteases and methods of use thereof
  申请人：Pardes Biosciences, Inc.

  公开号：US11312704B2

  公开（公告）日：2022-04-26

  The disclosure provides compounds, such as compounds of Formula II, with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.

  本公开提供了具有弹头的化合物，如式 II 化合物，以及它们在治疗医学疾病或紊乱（如病毒感染）中的用途。还提供了药物组合物和制造各种带弹头化合物的方法。这些化合物被认为可抑制蛋白酶，如 3C、CL- 或 3CL 样蛋白酶。
• ARTHROPODICIDAL AND NEMATICIDAL SULFONATES
  申请人：DUNLENA PTY. LIMITED

  公开号：EP0619811A1

  公开（公告）日：1994-10-19
• INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF
  申请人：Pardes Biosciences, Inc.

  公开号：US20210355111A1

  公开（公告）日：2021-11-18

  The disclosure provides compounds with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.
• [EN] ARTHROPODICIDAL AND NEMATICIDAL SULFONATES
  申请人：DUNLENA PTY. LTD.

  公开号：WO1993010096A1

  公开（公告）日：1993-05-27

  (EN) Arthropodicidal and nematicidal compounds of formulae (I, II), wherein Q is selected from the group Q-1, Q-2, Q-3, Q-4, Q-5 and Q-6, and R, R1, R2, X, Y and Z and R3 are as defined in the text, compositions containing the compounds and methods employing the compounds to control pests.(FR) L'invention concerne des composés arthropodicides et nématocides des formules (I) et (II) dans lesquelles Q est sélectionné dans le groupe Q-1, Q-2, Q-3, Q-4, Q-5 et Q-6, et R, R1, R2, X, Y, Z et R3 sont tels que définis dans le texte; l'invention concerne également les compositions contenant les composés et les procédés utilisant ces composés en vue de lutter contre les insectes et animaux nuisibles.
• Synthesis and Insecticidal Activity of Novel Pyridine Methanesulfonates
  作者：Bruce L. Finkelstein、Melissa A. Martz、Christopher J. Strock

  DOI：10.1002/(sici)1096-9063(199708)50:4<319::aid-ps595>3.0.co;2-e

  日期：1997.8

  A model has been developed which has led to the design and synthesis of novel 6-methanesulfonyloxypyridine-2-carboxamides with insecticidal activity, low mammalian toxicity and safety to aquatic organisms. The amides formed from amines with alpha branching (e.g. isopropyl and sec-butyl) demonstrated the highest level of activity. Rice nursery box field test results on laboratory raised insects gave insufficient control of the entire Japanese hopper spectrum to warrant further development of these compounds.