1-(6-Fluoro-4-phenylquinazolin-2-yl)guanidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-(6-Fluoro-4-phenylquinazolin-2-yl)guanidine
• 英文别名: 2-(6-fluoro-4-phenylquinazolin-2-yl)guanidine
• 化学式: C₁₅H₁₂FN₅
• mdl: MFCD04180852
• 分子量: 281.29
• InChiKey: LNOMSJXJZXOIPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  90.2
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• 2-Guanidino-4-arylchinazolines as nhe-3 inhibitors
  申请人：——

  公开号：US20040224965A1

  公开（公告）日：2004-11-11

  The invention relates to compounds of formula (I), where Ar=unsubstituted, or monosubstituted by R 3 , phenyl, or naphthyl; R 1 , R 2 =independently, A, OA, Hal or CF 3 ; R 3 =A, OA, Hal, or CF 3 ; A=1-6C alkyl and Hal=F, Cl, Br or I and the salts and solvates thereof as NHE3 inhibitors. 1
• Inhibitor for V-Atpase Activity, Antibacterial Agent, Medicine, Antibacterial Method and Screening Method
  申请人：Japan Science and Technology Agency

  公开号：US20220105076A1

  公开（公告）日：2022-04-07

  An inhibitor for Na + -translocating V-ATPase activity including a compound represented by where R 1 represents a group selected from a hydroxy group, an alkoxy group, and a haloalkoxy group, each bonded to an adjacent phenyl group via oxygen, or a group selected from a dialkylamino group, a heterocyclic amine, and a carboxylic acid amide group, each bonded to an adjacent phenyl group via nitrogen, or represents bromine, iodine, or a straight-chain hydrocarbon group. R 2 represents hydrogen or a haloalkoxy group. Z 1 represents an aliphatic hydrocarbon group, an alicyclic hydrocarbon group, an aromatic hydrocarbon group, or a heterocyclic group, each optionally having an arbitrary substituent and having a structure containing a double bond selected from between the group and an adjacent phenyl group. The symbol * represents a bond to the adjacent phenyl group.