3-butyl-5-(4-(tert-butyl)phenyl)oxazolidin-2-one | 1347703-35-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-butyl-5-(4-(tert-butyl)phenyl)oxazolidin-2-one
• 英文别名: 3-Butyl-5-(4-tert-butylphenyl)-1,3-oxazolidin-2-one；3-butyl-5-(4-tert-butylphenyl)-1,3-oxazolidin-2-one
• CAS: 1347703-35-8
• 化学式: C₁₇H₂₅NO₂
• 分子量: 275.391
• InChiKey: VHRLKDSVGMNZFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二氧化碳 、 1-butyl-2-(4-(tert-butyl)phenyl)aziridine 在 Br-Ph₃+PPEG₆₀₀P+Ph₃Br- 作用下， 50.0 ℃ 、5.0 MPa 条件下， 反应 6.0h， 以95%的产率得到3-butyl-5-(4-(tert-butyl)phenyl)oxazolidin-2-one
  参考文献：
  名称：

  从二氧化碳5-芳基-2-恶唑烷酮和氮丙啶区域选择性合成的Br -博士3 + PPEG 600 P +博士3溴-如在环境条件下的有效的，均匀的可回收催化剂

  摘要：

  聚乙二醇官能化鏻盐（BR -博士3 + PPEG 600 P +博士3溴- ）被发现是一种有效的，均匀的，可回收催化剂对CO的耦合2与各种相应的5-芳基-2-恶唑烷酮制备氮丙啶的在相对温和且无溶剂的条件下，具有良好的收率和出色的区域选择性。此外，该催化剂有效地再循环了四个连续的循环，而其催化活性和选择性没有任何明显的损失。

  DOI：

  10.1016/j.tetlet.2011.09.056

文献信息

• Polymer supported diol functionalized ionic liquids: An efficient, heterogeneous and recyclable catalyst for 5-aryl-2-oxazolidinones synthesis from CO2 and aziridines under mild and solvent free condition
  作者：Rahul A. Watile、Dattatraya B. Bagal、Krishna M. Deshmukh、Kishor P. Dhake、Bhalchandra M. Bhanage

  DOI：10.1016/j.molcata.2011.10.007

  日期：2011.12

  Polymer supported diol functionalized ionic liquids (PS-DFILXs) were investigated as an efficient, heterogeneous and recyclable catalyst for coupling of carbon dioxide (CO2) to aziridines providing high conversion with excellent regioselectivity towards 5-aryl-2-oxazolidinones under mild and solvent free conditions. The developed methodology was found to be applicable for wide variety of 1-alkyl-2-arylaziridines producing the corresponding 5-aryl-2-oxazolidinones with good yields and excellent regioselectivity. The hydroxyl groups present on vicinal carbon of PS-DFILX proved crucial for higher efficiency of catalyst. In addition, the catalyst could be reused for four consecutive recycles without significant loss in its catalytic activity and selectivity. Hence, the developed process represents environmentally benign chemical fixation pathway of CO2 for synthesis of 5-aryl-2-oxazolidinones under mild condition. (C) 2011 Elsevier B.V. All rights reserved.
• Regioselective synthesis of 5-aryl-2-oxazolidinones from carbon dioxide and aziridines using Br−Ph3+PPEG600P+Ph3Br− as an efficient, homogenous recyclable catalyst at ambient conditions
  作者：Rahul A. Watile、Dattatraya B. Bagal、Yogesh P. Patil、Bhalchandra M. Bhanage

  DOI：10.1016/j.tetlet.2011.09.056

  日期：2011.11

  phosphonium salt (Br−Ph3+PPEG600P+Ph3Br−) was found to be an efficient, homogenous, recyclable catalyst for coupling of CO2 with a variety of aziridines producing corresponding 5-aryl-2-oxazolidinones with good yields and excellent regioselectivity under relatively mild and solvent free conditions. Furthermore, the catalyst was effectively recycled for four consecutive cycles without any significant loss in

  聚乙二醇官能化鏻盐（BR -博士3 + PPEG 600 P +博士3溴- ）被发现是一种有效的，均匀的，可回收催化剂对CO的耦合2与各种相应的5-芳基-2-恶唑烷酮制备氮丙啶的在相对温和且无溶剂的条件下，具有良好的收率和出色的区域选择性。此外，该催化剂有效地再循环了四个连续的循环，而其催化活性和选择性没有任何明显的损失。