N-[2-[4-(methylsulfanylamino)phenyl]ethyl]-9-propan-2-yl-2-pyridin-3-ylpurin-6-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-[2-[4-(methylsulfanylamino)phenyl]ethyl]-9-propan-2-yl-2-pyridin-3-ylpurin-6-amine
• 化学式: C₂₂H₂₅N₇S
• 分子量: 419.5
• InChiKey: ZGSGTSYYKWFFCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• EXPANDED HEMATOPOIETIC STEM CELLS FROM CORD BLOOD AND THEIR THERAPEUTIC USE
  申请人：Novartis AG

  公开号：EP3524604A1

  公开（公告）日：2019-08-14

  The present invention relates to compounds and compositions for expanding the number of CD34+ cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (HSCs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages and immune system defense.

  本发明涉及用于扩大移植用CD34+细胞数量的化合物和组合物。本发明进一步涉及由扩增的造血干细胞（HSCs）组成的细胞群及其在自体或异体移植中的用途，用于治疗遗传性免疫缺陷和自身免疫性疾病以及各种造血疾病患者，以重建造血细胞系和免疫系统防御。
• COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS
  申请人：Novartis AG

  公开号：EP2350078B1

  公开（公告）日：2019-04-17
• COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS
  申请人：Fred Hutchinson Cancer Research Center

  公开号：US20180142212A1

  公开（公告）日：2018-05-24

  The present invention relates to methods, kits and compositions for expansion of hematopoietic stem/progenitor cells and providing hematopoietic function to human patients in need thereof. In one aspect, it relates to kits and compositions comprising a Notch agonist and an aryl hydrocarbon receptor antagonist. Also provided herein are methods for expanding the hematopoietic stem/progenitor cells using kits and compositions comprising a Notch agonist and an aryl hydrocarbon receptor antagonist. The hematopoietic stem/progenitor cells expanded using the disclosed kits, compositions and methods include human umbilical cord blood stem/progenitor cells, placental cord blood stem/progenitor cells and peripheral blood stem cells. The present invention also relates to administering hematopoietic stem/progenitor cells expanded using a combination of a Notch agonist and an aryl hydrocarbon receptor antagonist to a patient for short-term and/or long-term in vivo repopulation benefits.
• US9580426B2
  申请人：——

  公开号：US9580426B2

  公开（公告）日：2017-02-28
• US9834755B2
  申请人：——

  公开号：US9834755B2

  公开（公告）日：2017-12-05