4-phenyl-6H-cyclopenta[b]thiophene | 1254977-19-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-phenyl-6H-cyclopenta[b]thiophene
• CAS: 1254977-19-9
• 化学式: C₁₃H₁₀S
• 分子量: 198.288
• InChiKey: NQVUIVLXJGTJBS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-phenyl-1-(thien-2-yl)prop-2-yn-1-ol 在 三乙基硅烷 、 碘 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 1.5h， 以85%的产率得到4-phenyl-6H-cyclopenta[b]thiophene
  参考文献：
  名称：

  Iodine/Et3SiH: a novel reagent system for the synthesis of 3-aryl-1H-indenes from 1,3-diaryl propargyl alcohols

  摘要：

  1,3-Diaryl propargyl alcohols undergo smooth intramolecular Friedel-Crafts cyclization with triethylsilane in the presence of 10 mol % iodine 3-aryl-1H-indene derivatives in good yields in short reaction times. This is the first example on the synthesis of substituted indenes from 1,3-diaryl propargyl alcohols. The use of inexpensive and readily available molecular iodine makes this method quite simple, more convenient, and practical. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.08.061

文献信息

• Iodine/Et3SiH: a novel reagent system for the synthesis of 3-aryl-1H-indenes from 1,3-diaryl propargyl alcohols
  作者：B.V. Subba Reddy、B. Brahma Reddy、K.V. Raghavendra Rao、J.S. Yadav

  DOI：10.1016/j.tetlet.2010.08.061

  日期：2010.10

  1,3-Diaryl propargyl alcohols undergo smooth intramolecular Friedel-Crafts cyclization with triethylsilane in the presence of 10 mol % iodine 3-aryl-1H-indene derivatives in good yields in short reaction times. This is the first example on the synthesis of substituted indenes from 1,3-diaryl propargyl alcohols. The use of inexpensive and readily available molecular iodine makes this method quite simple, more convenient, and practical. (C) 2010 Elsevier Ltd. All rights reserved.