N-[3-(carbamoylcarbamoyl)thiophen-2-yl]-2-oxo-2H-chromene-3-carboxamide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: N-[3-(carbamoylcarbamoyl)thiophen-2-yl]-2-oxo-2H-chromene-3-carboxamide
• 英文别名: N-[3-(carbamoylcarbamoyl)thiophen-2-yl]-2-oxochromene-3-carboxamide
• 化学式: C₁₆H₁₁N₃O₅S
• 分子量: 357.3
• InChiKey: UDIMMCXTPOUNHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  156
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] SCREENING METHOD AND COMPOUNDS FOR MODULATING TELOMERASE ACTIVITY<br/>[FR] PROCEDE DE CRIBLAGE ET COMPOSES POUR MODULER L'ACTIVITE DE LA TELOMERASE
  申请人：WISTAR INST

  公开号：WO2011097600A1

  公开（公告）日：2011-08-11

  The present invention embraces methods for identifying compounds that modulate the activity of telomerase. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the TRBD, "thumb," "finger," and/or "palm" domain; or FP-pocket, PT-pocket or Th-pocket of telomerase and testing the compound for its ability to modulate the activity of telomerase. Compounds selected for interacting with the T-pocket or Fingers-Palm pocket of telomerase are also provided.