N-[(4-bromophenyl)methylideneamino]-2,4,6-trichloroaniline | 389593-55-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(4-bromophenyl)methylideneamino]-2,4,6-trichloroaniline
• CAS: 389593-55-9
• 化学式: C₁₃H₈BrCl₃N₂
• 分子量: 378.483
• InChiKey: SQKBGRKAPCCBOF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,4,6-三氯苯肼 、 对溴苯甲醛 以 甲醇 为溶剂， 反应 2.0h， 以55%的产率得到N-[(4-bromophenyl)methylideneamino]-2,4,6-trichloroaniline
  参考文献：
  名称：

  Synthesis of Substituted 1H-Indazoles from Arynes and Hydrazones

  摘要：

  The 1H-indazole skeleton can be constructed by a [3 + 2] annulation approach from arynes and hydrazones. Under different reaction conditions, both N-tosylhydrazones and N-aryl/alkylhydrazones can be used to afford a variety of indazoles. The former reaction affords 3-substituted indazoles either via in situ generated diazo compounds or through an annulation/elimination process. The latter reaction leads to 1,3-disubstituted indazoles likely through an annulation/oxidation process. The reactions operate under mild conditions and can accommodate aryl, vinyl, and less satisfactorily, alkyl groups.

  DOI：

  10.1021/jo202598e

文献信息

• Synthesis of Substituted 1<i>H</i>-Indazoles from Arynes and Hydrazones
  作者：Pan Li、Chunrui Wu、Jingjing Zhao、Donald C. Rogness、Feng Shi

  DOI：10.1021/jo202598e

  日期：2012.4.6

  The 1H-indazole skeleton can be constructed by a [3 + 2] annulation approach from arynes and hydrazones. Under different reaction conditions, both N-tosylhydrazones and N-aryl/alkylhydrazones can be used to afford a variety of indazoles. The former reaction affords 3-substituted indazoles either via in situ generated diazo compounds or through an annulation/elimination process. The latter reaction leads to 1,3-disubstituted indazoles likely through an annulation/oxidation process. The reactions operate under mild conditions and can accommodate aryl, vinyl, and less satisfactorily, alkyl groups.