1-phenylsulphonylhex-1-ene | 91787-23-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-phenylsulphonylhex-1-ene
• 英文别名: Hex-1-enylsulfonylbenzene
• CAS: 91787-23-4
• 化学式: C₁₂H₁₆O₂S
• 分子量: 224.324
• InChiKey: DMSHKKYCKFTGCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-[1-(phenylsulfonylhexan-2-yl)]-4-methylbenzenesulfonamide 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 18.0h， 以65%的产率得到1-phenylsulphonylhex-1-ene
  参考文献：
  名称：

  Highly regioselective ring-opening of aziridines with arenesulfinates on water: a facile access to β-amino/vinyl sulfones

  摘要：

  We have developed a LiBr catalyzed efficient synthesis of beta-amino sulfones from readily available aziridines and sodium sulfinates in good to excellent yields. The synthetic potential of beta-amino sulfones has also been demonstrated by their facile conversion to the corresponding vinyl sulfones. The use of water as reaction media, atom-economy and isolation of products by simple filtration in the case of solid beta-amino sulfones are certain green virtues of the synthetic protocol. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.12.028

文献信息

• Reactions of α-silylsulphones
  作者：David J. Ager

  DOI：10.1039/c39840000486

  日期：——

  α-Silylsulphones have been utilised to prepare vinylsulphones via the Peterson reaction and ketones by alkylation, reduction, and sila-Pummerer rearrangement.

  α-甲硅烷基砜已被用于通过彼得森反应和酮通过烷基化，还原和sila-Pummerer重排制备乙烯基砜。
• [EN] LAULIMALIDE DERIVATIVES<br/>[FR] DERIVES LAULIMALIDE
  申请人：KOSAN BIOSCIENCES INC

  公开号：WO2002064589A1

  公开（公告）日：2002-08-22

  Laulimalide compounds, intermediates thereto and methods for their preparation and methods for their use in the treatment of diseases characterized by cellular hyperproliferation. Formula (I).

  Laulimalide化合物，其中间体及其制备方法以及其在治疗细胞过度增殖所导致的疾病中的应用方法。公式(I)。
• Ager, David J., Journal of the Chemical Society. Perkin transactions I, 1986, p. 183 - 194
  作者：Ager, David J.

  DOI：——

  日期：——
• LAULIMALIDE DERIVATIVES
  申请人：Kosan Biosciences, Inc.

  公开号：EP1358186A1

  公开（公告）日：2003-11-05
• Highly regioselective ring-opening of aziridines with arenesulfinates on water: a facile access to β-amino/vinyl sulfones
  作者：Ruchi Chawla、Atul K. Singh、Lal Dhar S. Yadav

  DOI：10.1016/j.tet.2012.12.028

  日期：2013.2

  We have developed a LiBr catalyzed efficient synthesis of beta-amino sulfones from readily available aziridines and sodium sulfinates in good to excellent yields. The synthetic potential of beta-amino sulfones has also been demonstrated by their facile conversion to the corresponding vinyl sulfones. The use of water as reaction media, atom-economy and isolation of products by simple filtration in the case of solid beta-amino sulfones are certain green virtues of the synthetic protocol. (C) 2012 Elsevier Ltd. All rights reserved.