2,2,5-trimethyl-4-phenyl-3-azahexane 3-nitroxide | 606483-25-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2,5-trimethyl-4-phenyl-3-azahexane 3-nitroxide
• 英文别名: Agn-PC-0nchos；N-tert-butyl-N-(2-methyl-1-phenylpropyl)hydroxylamine
• CAS: 606483-25-4
• 化学式: C₁₄H₂₃NO
• 分子量: 221.343
• InChiKey: VOMJJZIGGPFTCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  异丙基溴化镁 、 N-叔丁基-Alpha-苯基硝酮 以 乙醚 为溶剂， 反应 0.17h， 生成 2,2,5-三甲基-4-苯基-3-氮杂己烷-3-氮氧自由基 、 2,2,5-trimethyl-4-phenyl-3-azahexane 3-nitroxide
  参考文献：
  名称：

  An ESR and HPLC-EC Assay for the Detection of Alkyl Radicals

  摘要：

  The correlation of lipid peroxidation with release of alkanes (RH) is considered a noninvasive method for the in vivo evaluation of oxidative stress. The formation of RH is believed to reflect a lipid hydroperoxide (LOOH)-dependent generation of alkoxyl radicals (LO.) that undergo, beta -scission with release of alkyl radicals (R-.). Alternatively, R-. could be spin-trapped with a nitrone before the formation of RH and analyzed by ESR. Extracts from the liver and lung of CCl4- and asbestos-treated rats that were previously loaded with nitrones exhibited ESR spectra suggesting the formation of iso-propyl, n-butyl, ethyl, and pentyl radical-derived nitroxides. In biological systems, various nitroxides with indistinguishable ESR spectra could be formed. Hence, experiments with N-tert-butyl-alpha -phenylnitrone (PBN) for spin trapping of R-. were carried out in which the nitroxides formed were separated and analyzed by HPLC with electrochemical detection (EC). The C1-5 homologous series of PBN nitroxides and hydroxylamines were synthesized, characterized by ESR, GC-MS, and HPLC-EC, and used as HPLC standards. For in vivo generation and spin trapping of R-., rats were loaded with CCl4 and PBN. The HPLC-EC chromatograms of liver extracts from CCl4-treated rats demonstrated the formation of both the nitroxide and hydroxylamine forms of PBN/(CCl3)-C-., as well as the formation of a series of unidentified PBN nitroxides and hydroxylamines. However, formation of PBN adducts with retention times similar to these of the PBN/C2-5 derivatives was not observed. In conclusion, we could not correlate the production of PBN-detectable alkyl radicals with the reported CCl4-dependent production Of C1-5 alkanes. We speculate that the major reason for this is the low steady-state concentrations of R-. produced because only a small fraction of LO. undergo,beta -scission to release R-..

  DOI：

  10.1021/tx015507h

文献信息

• COMPOUND AND POLYMER PREPARED THEREFROM
  申请人：INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

  公开号：US20160185882A1

  公开（公告）日：2016-06-30

  A compound, and a polymer prepared therefrom, are provided. The compound has a structure represented by Formula (I) or Formula (II): wherein A is R 1 is C 1-10 alkyl, C 5-12 cycloalkyl, C 6-14 aryl, C 3-12 heteroaryl, C 1-10 alkoxy, C 6-12 aryloxy, C 1-10 silyl, amino, thiol, or phosphonate group; R 2 is H, or C 1-10 alkyl; and, R 3 is C 1-10 alkoxy, C 1-10 alkanol, amine, or hydroxy.

  提供了一种化合物和由此制备的聚合物。该化合物具有由化学式(I)或化学式(II)表示的结构：其中A是R1是C1-10烷基，C5-12环烷基，C6-14芳基，C3-12杂芳基，C1-10烷氧基，C6-12芳氧基，C1-10硅烷基，氨基，硫醇基或膦酸酯基；R2是H或C1-10烷基；R3是C1-10烷氧基，C1-10烷醇基，胺基或羟基。
• PATTERN FORMING METHOD, UNDER COATING AGENT, AND LAMINATE
  申请人：Oji Holdings Corporation

  公开号：US20200048491A1

  公开（公告）日：2020-02-13

  It is an object of the present invention to provide a pattern forming method capable of easily forming a phase-separated structure with high accuracy, even in the case of widening the applicable range of a pattern size. The present invention relates to a pattern forming method comprising: applying an under coating agent onto a substrate, and applying a self-assembly composition for pattern formation to the surface of the substrate, onto which the under coating agent has been applied, and then forming a self-assembly film according to self-assembly phase separation, wherein the self-assembly composition for pattern formation comprises a block copolymer comprising a polymerization unit (a) having at least one selected from a structure represented by a formula ( 103 ) and a structure represented by a formula ( 104 ), and a polymerization unit (b) having a structure represented by a formula ( 105 ).

  本发明的目的是提供一种能够在扩大图案尺寸适用范围的情况下，轻松形成具有高精度的相分离结构的图案形成方法。本发明涉及一种图案形成方法，包括：在基板上涂覆底涂剂，并将用于图案形成的自组装组合物应用到已涂覆底涂剂的基板表面上，然后根据自组装相分离形成自组装膜，其中用于图案形成的自组装组合物包括一种嵌段共聚物，该嵌段共聚物包括至少具有下列结构之一的聚合单元（a）和具有下列结构的聚合单元（b）。
• TARGETED NITROXIDE AGENTS
  申请人：Wipf Peter

  公开号：US20140378444A1

  公开（公告）日：2014-12-25

  Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.

  本文提供了一种有用的自由基清除剂及其相关方法，特别是对线粒体具有特异性。这些化合物包括一个连接到线粒体靶向基团的亚硝基含有基团。这些化合物可以交联成二聚体而不会失去活性。本文还提供了一种方法，用于预防、缓解和治疗辐射引起的损伤。该方法包括将描述的化合物以有效的剂量和用药方案给患者，以预防、缓解或治疗辐射引起的损伤。
• Liquid (meth)acrylic syrup for impregnating a fibrous substrate and method for the production thereof, method for impregnating a fibrous substrate, and composite material produced after polymerisation of said pre-impregnated substrate
  申请人：Arkema France

  公开号：US10040934B2

  公开（公告）日：2018-08-07

  The invention relates to a liquid (meth)acrylic syrup for impregnating a fibrous substrate. The invention especially relates to a viscous liquid syrup mainly containing methacrylic or acrylic components. The invention also relates to a method for producing such a syrup. The invention relates further to a process for impregnating a fibrous substrate or long fibers with said viscous liquid syrup. The invention also relates to a fibrous substrate preimpregnated with said syrup, which is useful for the production of mechanical or structured parts or products. The invention also relates to a production method for producing mechanical or structured parts or items and to three-dimensional mechanical or structured parts produced by said method. The invention applies to the production of mechanical parts or structural elements made of impact-resistant thermoplastic composite material.

  本发明涉及一种用于浸渍纤维基材的液体（甲基）丙烯酸糖浆。本发明尤其涉及一种主要含有甲基丙烯酸或丙烯酸成分的粘性液体糖浆。本发明还涉及生产这种糖浆的方法。本发明还涉及一种用上述粘稠液体糖浆浸渍纤维基质或长纤维的工艺。本发明还涉及一种用上述糖浆预浸渍的纤维基材，它可用于生产机械或结构部件或产品。本发明还涉及一种生产机械或结构部件或产品的生产方法，以及用上述方法生产的三维机械或结构部件。本发明适用于生产由抗冲击热塑性复合材料制成的机械部件或结构件。
• Use of organic oxyimides as radical generators in plastics, method for generating radicals in plastics and use of said method
  申请人：FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

  公开号：US10364340B2

  公开（公告）日：2019-07-30

  The present invention relates to the use of phosphorus-containing organic oxyimides according to the general formula I described below as flame retardant for plastic materials, as radical generators in plastic materials and/or as stabilizers for plastic materials. The present invention relates in addition to a flame-retardant plastic material molding compound in which the previously described phosphorus-containing organic oxyimides are integrated, and also to a method for the production of the previously mentioned plastic material composition. Furthermore, the present invention relates to a molded part, a paint or a coating made of the previously mentioned flame-retardant plastic material composition.

  本发明涉及根据下述通式 I 所述的含磷有机氧化亚胺作为塑料材料阻燃剂、塑料材料自由基发生器和/或塑料材料稳定剂的用途。此外，本发明还涉及一种阻燃塑料材料模塑化合物，其中集成了前述的含磷有机氧化亚肟，本发明还涉及一种生产前述塑料材料组合物的方法。此外，本发明还涉及一种由前面提到的阻燃塑料材料组合物制成的模制件、涂料或涂层。