6-(2-Hydroxy-ethoxymethyl)-5-methyl-1,1-dioxo-2-phenyl-1,6-dihydro-2H-1λ⁶-[1,2,6]thiadiazin-3-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-(2-Hydroxy-ethoxymethyl)-5-methyl-1,1-dioxo-2-phenyl-1,6-dihydro-2H-1λ⁶-[1,2,6]thiadiazin-3-one
• 英文别名: 6-(2-Hydroxyethoxymethyl)-5-methyl-1,1-dioxo-2-phenyl-1,2,6-thiadiazin-3-one
• 化学式: C₁₃H₁₆N₂O₅S
• 分子量: 312.346
• InChiKey: TYSHIJJGCRXBHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  95.5
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  叔丁基二甲基氯硅烷 、 6-(2-Hydroxy-ethoxymethyl)-5-methyl-1,1-dioxo-2-phenyl-1,6-dihydro-2H-1λ⁶-[1,2,6]thiadiazin-3-one 在 吡啶 、 咪唑 作用下， 以 二氯甲烷 为溶剂， 反应 48.0h， 以98%的产率得到6-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxymethyl]-5-methyl-1,1-dioxo-2-phenyl-1,6-dihydro-2H-1λ⁶-[1,2,6]thiadiazin-3-one
  参考文献：
  名称：

  Synthesis and Antiviral Activity of Modified 1,2,6-Thiadiazine Dioxide Acyclonucleosides

  摘要：

  Modified 1,2,6-thiadiazine dioxide acyclonucleosides were synthesized using the silylation method. All the compounds were tested as antiviral agents in a wide variety of assay systems. With two compounds, some activity (20, 35 and 14 mu g/mL, respectively) was noted against herpes simplex virus, human cytomegalovirus and varicella-zoster virus.

  DOI：

  10.1080/07328319708001347

文献信息

• Synthesis and Antiviral Activity of Modified 1,2,6-Thiadiazine Dioxide Acyclonucleosides
  作者：A. I. Esteban、E. De Clercq、A. Martinez

  DOI：10.1080/07328319708001347

  日期：1997.3

  Modified 1,2,6-thiadiazine dioxide acyclonucleosides were synthesized using the silylation method. All the compounds were tested as antiviral agents in a wide variety of assay systems. With two compounds, some activity (20, 35 and 14 mu g/mL, respectively) was noted against herpes simplex virus, human cytomegalovirus and varicella-zoster virus.