6-(Propan-2-yloxy)pyridazin-3-amine | 1173150-07-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-(Propan-2-yloxy)pyridazin-3-amine
• 英文别名: 6-propan-2-yloxypyridazin-3-amine
• CAS: 1173150-07-6
• 化学式: C₇H₁₁N₃O
• mdl: MFCD20703171
• 分子量: 153.184
• InChiKey: QQEYAKUXPBQVFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.428
• 拓扑面积：
  61
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-(Propan-2-yloxy)pyridazin-3-amine 、 2,6-二氟苯甲酰异氰酸酯 以 二氯甲烷 为溶剂， 以90%的产率得到2,6-difluoro-N-[(6-propan-2-yloxypyridazin-3-yl)carbamoyl]benzamide
  参考文献：
  名称：

  Design, Synthesis, and Bioactivity Study of Novel Benzoylpyridazyl Ureas

  摘要：

  A series of novel benzoylpyridazyl ureas were designed and synthesized from maleic anhydride and hydrazine monohydrate. These benzoylureas were identified by H-1 NMR spectroscopy and element analysis. The bioactivities of the new compounds were evaluated. These compounds exhibited larvicidal activities against oriental armyworm, and in particular, compound 13 displayed comparable activity to the commercial insecticide Hexaflumuron. Most of these compounds also had some larvicidal activities against mosquito. Interestingly, some compounds showed good plant growth regulatory activities.

  DOI：

  10.1021/jf900882c
• 作为产物：
  描述：

  3-氨基-6-氯哒嗪 、 异丙醇 在 sodium 作用下， 生成 6-(Propan-2-yloxy)pyridazin-3-amine
  参考文献：
  名称：

  2-Phenylimidazo[1,2-b]pyridazine derivatives highly active against Haemonchus contortus

  摘要：

  A series of 2-phenylimidazo[1,2-b]pyridazine derivatives were synthesized and evaluated for their in vitro anthelmintic activity against Haemonchus contortus. The most active compounds had in vitro LD(99) values of 30 nM, which is comparable to that of the benchmark commercial nematocide, Ivermectin. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.05.096

文献信息

• 2-Phenylimidazo[1,2-b]pyridazine derivatives highly active against Haemonchus contortus
  作者：Abdelselam Ali、Teresa Cablewski、Craig L. Francis、Ashit K. Ganguly、Roger M. Sargent、David G. Sawutz、Kevin N. Winzenberg

  DOI：10.1016/j.bmcl.2011.05.096

  日期：2011.7

  A series of 2-phenylimidazo[1,2-b]pyridazine derivatives were synthesized and evaluated for their in vitro anthelmintic activity against Haemonchus contortus. The most active compounds had in vitro LD(99) values of 30 nM, which is comparable to that of the benchmark commercial nematocide, Ivermectin. (C) 2011 Elsevier Ltd. All rights reserved.
• Design, Synthesis, and Bioactivity Study of Novel Benzoylpyridazyl Ureas
  作者：Ranfeng Sun、Yonglin Zhang、Fuchun Bi、Qingmin Wang

  DOI：10.1021/jf900882c

  日期：2009.7.22

  A series of novel benzoylpyridazyl ureas were designed and synthesized from maleic anhydride and hydrazine monohydrate. These benzoylureas were identified by H-1 NMR spectroscopy and element analysis. The bioactivities of the new compounds were evaluated. These compounds exhibited larvicidal activities against oriental armyworm, and in particular, compound 13 displayed comparable activity to the commercial insecticide Hexaflumuron. Most of these compounds also had some larvicidal activities against mosquito. Interestingly, some compounds showed good plant growth regulatory activities.