1-(4-Ethylsulfanylphenyl)guanidine

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 1-(4-Ethylsulfanylphenyl)guanidine
• 英文别名: 2-(4-ethylsulfanylphenyl)guanidine
• 化学式: C₉H₁₃N₃S
• 分子量: 195.288
• InChiKey: HQTQZLOBGMCPIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  89.7
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(ethylsulfanyl)-4-nitrobenzene 在 盐酸 、 tin(ll) chloride 作用下， 以 乙醚 为溶剂， 反应 2.25h， 生成 1-(4-Ethylsulfanylphenyl)guanidine
  参考文献：
  名称：

  Synthesis and in vitro antifungal activity of 4-substituted phenylguanidinium salts

  摘要：

  A series of 4-substituted phenylguanidinium derivatives was synthesized and its antimicrobial activity was evaluated in vitro against eight potentially pathogenic strains of fungi.

  DOI：

  10.1016/j.farmac.2004.03.001

文献信息

• Biguanide derivatives, manufacturing method thereof, and disinfectants containing the derivatives
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0507317A2

  公开（公告）日：1992-10-07

  The invention presents a biguanide derivative or its salt expressed by a formula: (where R1 and R2 are as defined in Specification), or formula: (where A and R3 is as defined in specification). This biguanide derivative or its salt is preferably used as the effective amount of a disinfectant for humans, animals, medical appliances, etc.

  本发明提出了一种由式表示的双胍衍生物或其盐： (其中 R1 和 R2 如说明书中所定义），或式 (式中A和R3的定义见说明书）。这种双胍衍生物或其盐最好用作人、动物、医疗器械等有效量的消毒剂。
• Synthesis and in vitro antifungal activity of 4-substituted phenylguanidinium salts
  作者：Gabriela Braunerová、Vladimír Buchta、Luis Silva、Jiří Kuneš、Karel Palát

  DOI：10.1016/j.farmac.2004.03.001

  日期：2004.6

  A series of 4-substituted phenylguanidinium derivatives was synthesized and its antimicrobial activity was evaluated in vitro against eight potentially pathogenic strains of fungi.