[(2R)-2-[[4-(2-azidoethoxy)-3-methoxyphenyl]methyl-carbamothioylamino]-1-phenylpropan-2-yl] 2,2-dimethylpropanoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(2R)-2-[[4-(2-azidoethoxy)-3-methoxyphenyl]methyl-carbamothioylamino]-1-phenylpropan-2-yl] 2,2-dimethylpropanoate
• 化学式: C25H33N5O4S
• 分子量: 499.6
• InChiKey: HKDHNUKGVQVJQW-RUZDIDTESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  35
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  121
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] SIMPLIFIED RESINIFERATOXIN ANALOGUES AS VANILLOID RECEPTOR AGONIST SHOWING EXCELLENT ANALGESIC ACTIVITY AND THE PHARMACEUTICAL CO MPOSITIONS CONTAINING THE SAME<br/>[FR] ANALOGUES SIMPLIFIES DE RESINIFERATOXINE UTILISES EN TANT QU'AGONISTES DES RECEPTEURS VANILLOIDE PRESENTANT UNE EXCELLENTE ACTIVITE ANALGESIQUE, ET COMPOSITIONS PHARMACEUTIQUES CONTENANT CES ANALOGUES
  申请人：DIGITAL BIOTECH CO LTD

  公开号：WO2003027064A1

  公开（公告）日：2003-04-03

  The present invention is related to new vanilloid analogues containing resiniferatoxin pharmacophores, pharmaceutical compositions comprising such analogues, and their uses as vanilloid receptor agonistsand potent analgesics.The present invention provides a pharmaceutical composition for preventing, alleviating or treating pain, acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neutopathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fervescence, stomach-duodenal ulcer, inflammatory bowel disease, inflammatory disease or urgent urinary incontinence.