作者:Stefania F. Musolino、O. Stephen Ojo、Nicholas J. Westwood、James E. Taylor、Andrew D. Smith
DOI:10.1002/chem.201604788
日期:2016.12.23
The non‐enzymatic acylative kineticresolution of challenging aryl–alkenyl (sp2 vs. sp2) substituted secondaryalcohols is described, with effective enantiodiscrimination achieved using the isothiourea organocatalyst HyperBTM (1 mol %) and isobutyric anhydride. The kineticresolution of a wide range of aryl–alkenyl substituted alcohols has been evaluated, with either electron‐rich or naphthyl aryl
描述了具有挑战性的芳基-烯基(sp 2与 sp 2 )取代的仲醇的非酶酰化动力学拆分,并使用异硫脲有机催化剂 HyperBTM(1 mol%)和异丁酸酐实现了有效的对映区分。已经评估了各种芳基-烯基取代醇的动力学拆分,其中富电子或萘基芳基取代基与未取代的乙烯基取代基相结合,提供了最高的选择性( S =2-1980)。演示了使用该方案对模型芳基-乙烯基(sp 2与 sp 2 )取代的仲醇进行克级(2.5 g)动力学拆分,可获取每种产物对映体的 >1 g 99:1呃。
Synthesis of Enantiopure 1-Arylprop-2-en-1-ols and Their <i>tert</i>-Butyl Carbonates
作者:Jan Štambaský、Andrei V. Malkov、Pavel Kočovský
DOI:10.1021/jo801874r
日期:2008.11.21
Enantiomerically pure 1-arylpropenols 8 have been prepared by resolution of the corresponding racemates, using the lipase formulation Novozyme 435. Deprotonation of the latter alcohols with n-BuLi, followed by derivatization with (t-BUO)(2)CO, afforded the corresponding carbonates 5. Optimization of the process is presented.
Iridium-Catalyzed Enantioselective Synthesis of Allylic Alcohols: Silanolates as Hydroxide Equivalents
作者:Isabelle Lyothier、Christian Defieber、Erick M. Carreira
DOI:10.1002/anie.200602408
日期:2006.9.18
Synthesis of enantiopure glycidol derivatives via a one-pot two-step enzymatic cascade
作者:Yu-Chang Liu、Yan Liu、Zhong-Liu Wu
DOI:10.1039/c4ob02186j
日期:——
An enzymatic cascade reaction employing anS-specific ketoreductase and a styrene monooxygenase to synthesize enantiopure glycidol derivatives is described.