4-Pyrimidinol, 5-ethyl-6-methyl- | 103980-63-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-Pyrimidinol, 5-ethyl-6-methyl-
• 英文别名: 5-ethyl-4-methyl-1H-pyrimidin-6-one
• CAS: 103980-63-8
• 化学式: C₇H₁₀N₂O
• 分子量: 138.17
• InChiKey: YFQYHKFLGGGCFR-UHFFFAOYSA-N

物化性质

• 熔点：
  275 °C
• 沸点：
  221.2±23.0 °C(Predicted)
• 密度：
  1.13±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2933599090

文献信息

• [EN] COMPOSITIONS AND METHODS OF TREATING DRUG-RESISTANT RETROVIRAL INFECTIONS<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE TRAITEMENT D'INFECTIONS RÉTROVIRALES PHARMACORÉSISTANTES
  申请人：TRANA DISCOVERY INC

  公开号：WO2012079032A2

  公开（公告）日：2012-06-14

  Methods of treating drug-resistant retroviral infections, such as those caused by drug- resistant HIV-I, HIV-II, and HIV-III, are disclosed. The methods involve administering a compound that is an inhibitor of retroviral propagation. The inhibitors inhibits the ability of any portion of the HIV genome involved in reverse transcription to bind to or associate with a host cell tRNA, or the inhibitor disrupts the RNA/RNA complex formed between the viral genome and the human tRNA primer, or the binding or association of the host cell tRNA to a retroviral genome initiates, primes, or facilitates reverse transcription of the retroviral genome in the absence of the administered compound.