1-(2-Hydroxyethoxymethyl)-3-[(3-phenylmethoxyphenyl)methyl]-1,3-diazinane-2,4,6-trione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-(2-Hydroxyethoxymethyl)-3-[(3-phenylmethoxyphenyl)methyl]-1,3-diazinane-2,4,6-trione
• 化学式: C₂₁H₂₂N₂O₆
• 分子量: 398.4
• InChiKey: VLTHYZVOMIURJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  96.4
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] METHODS OF REDUCING TOXICITY OF CHEMOTHERAPEUTIC AND ANTIVIRAL AGENTS WITH ACYLATED PYRIMIDINE NUCLEOSIDES<br/>[FR] PROCEDES DE REDUCTION DE LA TOXICITE D'AGENTS CHIMIOTHERAPEUTIQUES ET ANTIVIRAUX AVEC DES NUCLEOSIDES DE PYRIMIDE ACYLES
  申请人：PRO-NEURON, INC.

  公开号：WO1996040165A1

  公开（公告）日：1996-12-19

  (EN) The subject invention discloses compounds, compositions and methods for treatment and prevention of toxicity due to chemotherapeutic agents and antiviral agents. Disclosed are acylated derivatives of non-methylated pyrimidine nucleosides. These compounds are capable of attenuating damage to the hematopoietic system in animals receiving antiviral or antineoplastic chemotherapy.(FR) La présente invention se rapporte à des composés, des compositions et des procédés de traitement et de prévention de la toxicité due à des agents chimiothérapeutiques et antiviraux. L'invention se rapporte également à des dérivés acylés de nucléosides de pyrimidine non méthylés. Ces composés peuvent atténuer les lésions du système hématopoïétique chez des animaux subissant une chimiothérapie antivirale ou antinéoplasique.

  该发明涉及用于治疗和预防化疗药物和抗病毒药物引起的毒性的化合物、组合物和方法。揭示了非甲基化嘧啶核苷酸的酰化衍生物。这些化合物能够减轻接受抗病毒或抗肿瘤化疗的动物的造血系统损伤。
• COMPOSITIONS AND METHODS FOR TREATMENT OF MITOCHONDRIAL DISEASES
  申请人：——

  公开号：US20010005719A1

  公开（公告）日：2001-06-28

  Compounds, compositions, and methods are provided for treatment of disorders related to mitochondrial dysfunction. The methods comprise administering to a mammal a composition containing pyrimidine nucleotide precursors in amounts sufficient to treat symptoms resulting from mitochondrial respiratory chain deficiencies.

  提供了用于治疗与线粒体功能障碍相关的疾病的化合物、组合物和方法。该方法包括向哺乳动物注射含有嘧啶核苷酸前体的组合物，其量足以治疗因线粒体呼吸链缺陷而导致的症状。
• Compositions and methods for treatment of mitochondrial diseases
  申请人：Pro-Neuron, Inc.

  公开号：US20010016576A1

  公开（公告）日：2001-08-23

  Compounds, compositions, and methods are provided for treatment of disorders related to mitochondrial dysfunction. The methods comprise administering to a mammal a composition containing pyrimidine nucleotide precursors in amounts sufficient to treat symptoms resulting from mitochondrial respiratory chain deficiencies.

  本发明提供了用于治疗与线粒体功能障碍相关的疾病的化合物、组合物和方法。该方法包括向哺乳动物注射含有嘧啶核苷酸前体的组合物，其用量足以治疗由于线粒体呼吸链缺陷引起的症状。
• TREATMENT OF CHEMOTHERAPEUTIC AGENT AND ANTIVIRAL AGENT TOXICITY WITH ACYLATED PYRIMIDINE NUCLEOSIDES
  申请人：——

  公开号：US20010025032A1

  公开（公告）日：2001-09-27

  The subject invention discloses compounds, compositions and methods for treatment and prevention of toxicity due to chemotherapeutic agents and antiviral agents. Disclosed are acylated derivatives of non-methylated pyrimidine nucleosides. These compounds are capable of attenuating damage to the hematopoietic system in animals receiving antiviral or antineoplastic chemotherapy.

  本发明涉及化合物、组合物和治疗及预防化疗药物和抗病毒药物毒性的方法。本发明揭示了非甲基嘧啶核苷酸的酰化衍生物。这些化合物能够减轻接受抗病毒或抗肿瘤化疗的动物的造血系统损伤。
• Pyrimidine nucleotide precursors for treatment of inflammatory hepatitis
  申请人：Wellstat Therapeutics Corporation

  公开号：EP1486210A1

  公开（公告）日：2004-12-15

  Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic inflammation are disclosed.

  本研究公开了嘧啶核苷酸前体（包括胞苷、尿苷和乳清酸的酰基衍生物）和尿苷磷酸化酶抑制剂，以及它们在增强对败血症或全身性炎症的抵抗力方面的用途。