N-acetyl 4-phenyl-oxazolidin-2-one | 63204-84-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: N-acetyl 4-phenyl-oxazolidin-2-one
• 英文别名: 3-acetyl-4-phenyl-oxazolidin-2-one；(4R)-3-Acetyl-4-phenyl-oxazolidin-2-one；3-acetyl-4-phenyl-1,3-oxazolidin-2-one
• CAS: 63204-84-2
• 化学式: C₁₁H₁₁NO₃
• 分子量: 205.213
• InChiKey: XALZBROPIGPSAQ-UHFFFAOYSA-N

物化性质

• 熔点：
  98-99 °C(Solv: chloroform (67-66-3); hexane (110-54-3))
• 沸点：
  383.7±31.0 °C(Predicted)
• 密度：
  1.260±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-acetyl 4-phenyl-oxazolidin-2-one 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 0.5h， 以84%的产率得到1-(乙酰氨基)-1-苯乙烯
  参考文献：
  名称：

  An efficient synthesis of styrenyl enamides from 4-aryl-2-oxazolidinones in the presence of strong base

  摘要：

  Efficient synthesis of styrenyl enamides can be achieved from the corresponding 4-aryl-2-oxazolidinones, 2-thioxooxazolidines, and 2-thioxothiazolidines in the presence of the strong base lithium diisopropylamine. The reaction proceeded efficiently to achieve the enamides in good to excellent yields (up to 92%). This reaction provides an easy, rapid, and good-yielding method for the synthesis of styrenyl enamides. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.08.026

文献信息

• [EN] NOVEL PROCESSES FOR THE PRODUCTION OF USEFUL INTERMEDIATES<br/>[FR] NOUVEAUX PROCEDES DE PRODUCTION D'INTERMEDIAIRES UTILES
  申请人：SOD CONSEILS RECH APPLIC

  公开号：WO2006033011A1

  公开（公告）日：2006-03-30

  The present application relates to a new process for the asymmetric production of 3-(pyridin-4-yl)-3-hydroxy-pentanoic acid derivatives, which are useful intermediates in the manufacture of compounds that are known to show antiproliferative activity.

  本申请涉及一种新的过程，用于不对称生产3-(吡啶-4-基)-3-羟基戊酸衍生物，这些衍生物是制造已知具有抗增殖活性化合物的中间体。
• [EN] NECROSIS INHIBITORS<br/>[FR] INHIBITEURS DE NÉCROSE
  申请人：NAT INST OF BIOLOG SCIENCES BEIJING

  公开号：WO2016101887A1

  公开（公告）日：2016-06-30

  The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

  该发明提供了抑制细胞坏死和/或人类受体相互作用蛋白1激酶（RIP1）的酰胺，包括相应的磺酰胺，以及其药用盐、氢化物和立体异构体。这些化合物用于制备药物组合物，并用于制备方法，包括用有效量的化合物或组合物治疗需要的人，并检测人的健康或状况的改善。
• Absolute Configuration of the Phenylpropanoid Isolated from<i>Peperomia tetraphylla</i>
  作者：Yanchao Yu、Xiaowei Lu、Wenju Wu、Yikang Wu、Bo Liu

  DOI：10.1002/cjoc.201300648

  日期：2013.10

  A recently identified phenylpropanoid isolated from Peperomia tetraphylla was synthesized in enantiopure forms using an aldol condensation of enantiopure (R)‐N‐acetyl 4‐phenyl‐oxazolidin‐2‐one as the key step. With the aid of the single crystal X‐ray crystallographic analysis of the synthetic sample, the configuration for the natural product was unambiguously established. Corrected/updated 13C NMR

  以对映纯（R）‐N‐乙酰基‐4‐苯基‐恶唑烷丁2‐1的醛醇缩合为关键步骤，以对映纯形式合成了最近鉴定自四叶Peperomiatetraphylla的苯基丙烷。借助合成样品的单晶X射线晶体学分析，可以明确地确定天然产物的构型。还介绍了校正/更新的13 C NMR和旋光性。
• Novel Processes for the Production of Useful Intermediates
  申请人：DIOLEZ Christian

  公开号：US20090247563A9

  公开（公告）日：2009-10-01

  The present application relates to a new process for the asymmetric production of 3-(pyridin-4-yl)-3-hydroxy-pentanoic acid derivatives, which are useful intermediates in the manufacture of compounds that are known to show antiproliferative activity.

  本申请涉及一种新的过程，用于不对称生产3-(吡啶-4-基)-3-羟基戊酸衍生物，这些衍生物是制造已知具有抗增殖活性化合物的有用中间体。
• NOVEL PROCESSES FOR THE PRODUCTION OF USEFUL INTERMEDIATES
  申请人：Diolez Christian

  公开号：US20100168426A1

  公开（公告）日：2010-07-01

  The present application relates to a new process for the asymmetric production of 3-(pyridin-4-yl)-3-hydroxy-pentanoic acid derivatives, which are useful intermediates in the manufacture of compounds that are known to show antiproliferative activity.

  本申请涉及一种新的过程，用于不对称生产3-(吡啶-4-基)-3-羟基戊酸衍生物，这些衍生物是制造已知具有抗增殖活性化合物的有用中间体。