altersolanol B | 22350-90-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: altersolanol B
• 英文别名: Dactylarin；(2R,3S)-2,3,8-trihydroxy-6-methoxy-3-methyl-2,4-dihydro-1H-anthracene-9,10-dione
• CAS: 22350-90-9
• 化学式: C₁₆H₁₆O₆
• 分子量: 304.299
• InChiKey: AAHQQIFXAQHGBD-WBMJQRKESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  altersolanol B 、 丙酮 在 高氯酸 作用下， 反应 2.0h， 以88%的产率得到altersolanol B 2,3-O-acetonide
  参考文献：
  名称：

  Bioactive Anthraquinone Derivatives from the Mangrove-Derived Fungus Stemphylium sp. 33231

  摘要：

  Four new anthraquinone derivatives (1-4) and four new alterporriol-type anthranoid dimers (14-17), along with 17 analogues, were isolated from the solid rice fermentation of the fungus Stemphylium sp. 33231 obtained from the mangrove Bruguiera sexangula var. rhynchopetala collected from the South China Sea. Their structures were elucidated using comprehensive spectroscopic methods. The absolute configurations of 1, 3, and 4 were determined by single-crystal X-ray diffraction of their derivatives (1a, 3b, and 4a). The absolute configurations of the chiral 17-19 were determined by comparing their CD spectra with 21. The inhibitory activities of most of the compounds against seven terrestrial pathogenic bacteria and two cancer cell lines were evaluated.

  DOI：

  10.1021/np500340y
• 作为产物：
  描述：

  2-O-acetylaltersolanol B 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 0.08h， 以92%的产率得到altersolanol B
  参考文献：
  名称：

  Bioactive Anthraquinone Derivatives from the Mangrove-Derived Fungus Stemphylium sp. 33231

  摘要：

  Four new anthraquinone derivatives (1-4) and four new alterporriol-type anthranoid dimers (14-17), along with 17 analogues, were isolated from the solid rice fermentation of the fungus Stemphylium sp. 33231 obtained from the mangrove Bruguiera sexangula var. rhynchopetala collected from the South China Sea. Their structures were elucidated using comprehensive spectroscopic methods. The absolute configurations of 1, 3, and 4 were determined by single-crystal X-ray diffraction of their derivatives (1a, 3b, and 4a). The absolute configurations of the chiral 17-19 were determined by comparing their CD spectra with 21. The inhibitory activities of most of the compounds against seven terrestrial pathogenic bacteria and two cancer cell lines were evaluated.

  DOI：

  10.1021/np500340y

文献信息

• TOMM6-INTERACTING EXTRACTS AND COMPOUNDS FOR USE IN THE TREATMENT AND PROPHYLAXIS OF NERVOUS SYSTEM DISEASES, ATHEROSCLEROSIS, HEPATITIS B INFECTION AND HUMAN PAPILLOMA VIRUS (HPV) INFECTION
  申请人：ETH ZURICH

  公开号：US20210186947A1

  公开（公告）日：2021-06-24

  The present invention is directed to a TOMM6 (Translocase of Outer Membrane 6 kDa subunit homologue; Mitochondrial import receptor subunit TOM6 homolog)-interacting plant or fungal extract comprising an anthraquinone or anthraquinone derivative, a TOMM6-interacting anthraquinone or anthraquinone derivative, and TOMM6-interacting compounds for use in the treatment or prophylaxis of a nervous system disease, atherosclerosis, Hepatitis B infection and/or human papilloma virus (HPV) infection. Furthermore, the present invention relates to a corresponding method of therapeutic or prophylactic treatment of a nervous system disease or disorder, atherosclerosis, Hepatitis B infection and/or human papilloma virus (HPV) infection, as well as to a method for the identification of a TOMM6-interacting compound or composition. Also, the present invention provides a non-human transgenic animal expressing a transgenic, preferably human TOMM6 or a TOMM6 homolog.
• Bioactive Anthraquinone Derivatives from the Mangrove-Derived Fungus <i>Stemphylium</i> sp. 33231
  作者：Xue-Ming Zhou、Cai-Juan Zheng、Guang-Ying Chen、Xiao-Ping Song、Chang-Ri Han、Gao-Nan Li、Yan-Hui Fu、Wen-Hao Chen、Zhi-Gang Niu

  DOI：10.1021/np500340y

  日期：2014.9.26

  Four new anthraquinone derivatives (1-4) and four new alterporriol-type anthranoid dimers (14-17), along with 17 analogues, were isolated from the solid rice fermentation of the fungus Stemphylium sp. 33231 obtained from the mangrove Bruguiera sexangula var. rhynchopetala collected from the South China Sea. Their structures were elucidated using comprehensive spectroscopic methods. The absolute configurations of 1, 3, and 4 were determined by single-crystal X-ray diffraction of their derivatives (1a, 3b, and 4a). The absolute configurations of the chiral 17-19 were determined by comparing their CD spectra with 21. The inhibitory activities of most of the compounds against seven terrestrial pathogenic bacteria and two cancer cell lines were evaluated.