1,3,3a,8b-Tetrahydro-benzo[b]thieno[3,4-d]thiophene 2,2-dioxide | 194085-43-3

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 1,3,3a,8b-Tetrahydro-benzo[b]thieno[3,4-d]thiophene 2,2-dioxide
• 英文别名: 1,3,3a,8b-Tetrahydrothieno[3,4-b][1]benzothiole 2,2-dioxide
• CAS: 194085-43-3
• 化学式: C₁₀H₁₀O₂S₂
• 分子量: 226.32
• InChiKey: DQPCHRSCAASZLL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  67.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,3,3a,8b-Tetrahydro-benzo[b]thieno[3,4-d]thiophene 2,2-dioxide 在 N-溴代丁二酰亚胺(NBS) 、 偶氮二异丁腈 作用下， 以 苯 为溶剂， 反应 1.5h， 以97%的产率得到1,3-Dihydrothieno[3,4-b][1]benzothiole 2,2-dioxide
  参考文献：
  名称：

  Preparation and Reactions of Benzofurano-, Indolo-, and Benzothieno-3-sulfolenes

  摘要：

  Benzofurano-, N-tosylindolo-, and benzothieno-3-sulfolenes have been prepared efficiently via their dihydro analogues. These fused 3-sulfolenes serve as ideal precursors for the corresponding heteroaromatic o-quinodimethanes. Derivatives of these 3-sulfolenes bearing bromo or alkyl group substitution from which substituted heteroaromatic o-quinodimethanes are generated have also been synthesized.

  DOI：

  10.1021/jo980044e
• 作为产物：
  描述：

  2-溴硫代苯酚 在 吡啶 、 N-溴代丁二酰亚胺(NBS) 、 偶氮二异丁腈 、 三正丁基氢锡 作用下， 以 二氯甲烷 、 苯 为溶剂， 反应 75.0h， 生成 1,3,3a,8b-Tetrahydro-benzo[b]thieno[3,4-d]thiophene 2,2-dioxide
  参考文献：
  名称：

  Preparation and Reactions of Benzofurano-, Indolo-, and Benzothieno-3-sulfolenes

  摘要：

  Benzofurano-, N-tosylindolo-, and benzothieno-3-sulfolenes have been prepared efficiently via their dihydro analogues. These fused 3-sulfolenes serve as ideal precursors for the corresponding heteroaromatic o-quinodimethanes. Derivatives of these 3-sulfolenes bearing bromo or alkyl group substitution from which substituted heteroaromatic o-quinodimethanes are generated have also been synthesized.

  DOI：

  10.1021/jo980044e

文献信息

• Preparation of benzofurano-, benzothieno-, indolo-3-sulfolenes as precursors for heteroaromatic o-quinodimethanes
  作者：Chung-Wen Ko、Ta-shue Chou

  DOI：10.1016/s0040-4039(97)01183-0

  日期：1997.7

  Efficient routes have been developed for the synthesis of benzofurano-3-sulfolene 16, benzofurano-3-sulfolene 16, and N-tosylindolo-3-sulfolene 18. These compounds are ideal precursors for the corresponding heteroaromatic alpha-quinodimethanes. (C) 1997 Elsevier Science Ltd.
• Preparation and Reactions of Benzofurano-, Indolo-, and Benzothieno-3-sulfolenes
  作者：Chung-Wen Ko、Ta-shue Chou

  DOI：10.1021/jo980044e

  日期：1998.7.1

  Benzofurano-, N-tosylindolo-, and benzothieno-3-sulfolenes have been prepared efficiently via their dihydro analogues. These fused 3-sulfolenes serve as ideal precursors for the corresponding heteroaromatic o-quinodimethanes. Derivatives of these 3-sulfolenes bearing bromo or alkyl group substitution from which substituted heteroaromatic o-quinodimethanes are generated have also been synthesized.