(E)-1,3-dimethyl-N-[(E)-(1-methyl-2-phenylindol-1-ium-3-ylidene)amino]benzimidazol-2-imine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: (E)-1,3-dimethyl-N-[(E)-(1-methyl-2-phenylindol-1-ium-3-ylidene)amino]benzimidazol-2-imine
• 化学式: C24H22N5+
• 分子量: 380.5
• InChiKey: XHIDXWZNFJYWCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.57
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  24.8
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• COMPOUNDS AND METHODS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES
  申请人：Horrigan Stephen K.

  公开号：US20100093611A1

  公开（公告）日：2010-04-15

  Methods of treating, ameliorating, preventing, or reducing the risk of developing an auto-immune disease and/or an inflammatory condition, such as systemic lupus erythematosus, in a patient, such as a human being, using a therapeutically effective amount of an agent(s) that inhibits the activity of one or more of histone deacetylase (HDAC), I K B kinase (IKK-2), nuclear factor kB (NF-kB), ubiquitin/proteasome and Janus kinase (JAK) are disclosed. Compounds useful in such methods are also presented.