2-(2,4-dimethoxy-phenyl)-propylamine | 59907-78-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2,4-dimethoxy-phenyl)-propylamine
• 英文别名: 2-(2,4-Dimethoxyphenyl)propan-1-amine
• CAS: 59907-78-7
• 化学式: C₁₁H₁₇NO₂
• 分子量: 195.261
• InChiKey: QBJZNTXMWMLITR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(2,4-dimethoxy-phenyl)-propylamine 在 盐酸 作用下， 生成 α-methyldopamine
  参考文献：
  名称：

  Phenethylamines. IV. Dimethoxy and Dihydroxyphenyl-n-propylamines (β-Methyl-β-pheńethylamines)¹

  摘要：

  DOI：

  10.1021/ja01264a038
• 作为产物：
  描述：

  3-(2,4-dimethoxy-phenyl)-butyric acid amide 在 alkaline aqueous sodium hypobromite 作用下， 生成 2-(2,4-dimethoxy-phenyl)-propylamine
  参考文献：
  名称：

  Phenethylamines. IV. Dimethoxy and Dihydroxyphenyl-n-propylamines (β-Methyl-β-pheńethylamines)¹

  摘要：

  DOI：

  10.1021/ja01264a038

文献信息

• PHARMACEUTICAL COMPOSITIONS
  申请人：Charleston Laboratories Inc.

  公开号：EP2451274A1

  公开（公告）日：2012-05-16
• [EN] PHARMACEUTICAL COMPOSITIONS<br/>[FR] COMPOSITIONS PHARMACEUTIQUES
  申请人：CHARLESTON LAB INC

  公开号：WO2011006012A1

  公开（公告）日：2011-01-13

  Methods and compositions are provided which comprise effective amounts of analgesic to treat a subject, including reducing or eliminating an adverse effect associated with the analgesic.
• [EN] TREATING PAIN USING A COMPOSITION COMPRISING AN OPIOID AND AN ANTIEMETIC<br/>[FR] TRAITEMENT DE LA DOULEUR À L'AIDE D'UNE COMPOSITION COMPRENANT UN OPIOÏDE ET UN ANTIÉMÉTIQUE
  申请人：CHARLESTON LABORATORIES INC

  公开号：WO2017066488A1

  公开（公告）日：2017-04-20

  Provided herein are methods and compositions for effective treatment or prevention of pain, which also reduce or eliminate adverse effects associated with an opioid analgesic. In addition, provided herein are methods and compositions for treatment or prevention of pain, and for reducing or preventing retching in a subject. Also provided herein are methods and compositions for treatment or prevention of pain, and for reducing or preventing sleep disturbances. Also provided herein are methods and compositions for treatment or prevention of pain, and for reducing or preventing a sensory or affective quality associated with the pain, such as agonizing pain, in a subject. Compositions described herein may include an opioid analgesic and an antiemetic. Compositions described herein may further include a non-opioid analgesic.
• Phenethylamines. IV. Dimethoxy and Dihydroxyphenyl-n-propylamines (β-Methyl-β-pheńethylamines)¹
  作者：E. H. Woodruff

  DOI：10.1021/ja01264a038

  日期：1942.12