6,11-Dihydro-11-methyl-5H-dibenz azepin | 37478-89-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 6,11-Dihydro-11-methyl-5H-dibenz azepin
• 英文别名: 11-methyl-6,11-dihydro-5H-dibenzo[b,e]azepine；6,11-dihydro-11-methyl-5H-dibenzo[b,e]azepine；11-methyl-6,11-dihydro-5H-benzo[c][1]benzazepine
• CAS: 37478-89-0
• 化学式: C₁₅H₁₅N
• 分子量: 209.291
• InChiKey: LLOIFZXMOQAXNU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  6,11-Dihydro-11-methyl-5H-dibenz azepin 以79%的产率得到
  参考文献：
  名称：

  WARDROP A. W. H.; SAINSBURY G. L.; HARRISON J. M.; INCH T. D., J. CHEM. SOC. PERKIN TRANS., PART 1, , 1976, NO 12, 1279-1285

  摘要：

  DOI：
• 作为产物：
  描述：

  11-hydroxy-11-methyl-5,11-dihydro-dibenzo[b,e]azepin-6-one 在 lithium aluminium tetrahydride 、 水 、 sodium sulfate 作用下， 以 1,4-二氧六环 为溶剂， 反应 3.0h， 以61%的产率得到6,11-Dihydro-11-methyl-5H-dibenz azepin
  参考文献：
  名称：

  WO2007/25938

  摘要：

  公开号：

文献信息

• Non-Steroidal Compounds Useful as Glucocorticoid Receptor Modulators
  申请人：Plate Ralf

  公开号：US20080188459A1

  公开（公告）日：2008-08-07

  This invention relates to novel amino acid derivatives of formula (I) wherein the R groups have the following meanings: —R 1 is —H or -(1-4C)alkyl; —R 2 is —C(O)R 15 or —S(O) 2 R 15 ; —R 3 is —H, -(1-4C)alkyl or —OR 16 ; —R 4 is —H, -(1-4C)alkyl or —OR 16 ; —R 6 is —H or —C(R 16 )NOR 16 ; —R 7 is —H, -halogen, -cyano; -(1-6C)alkyl, -(2-6C)alkenyl or -(2-6C)alkynyl, all optionally substituted with -amino, -hydroxyl or -halogen; —R 8 is —H, -cyano, -halogen, -nitro; -(1-6C)alkyl, -(2-6C)alkenyl, -(2-6C)alkynyl or —O(1-6C)alkyl, all optionally substituted with -amino, -hydroxyl or -halogen; -(hetero)aryl, optionally substituted with -cyano, -halogen, -(1-4C)alkyl, -(1-4C)alkoxy, -(1-4C)alkoxy(1-4C)alkyl or -(hetero)aryl; —C(R 16 )NOR 16 ; —C(O)N(R 17 ) 2 ; —C(O)R18, —C(O)OR 19 , —NHC(O)R 20 , or —NHS(O) 2 R 21 ; —R 9 is —H, -halogen, -cyano, or -(1-4C)alkyl, optionally substituted with -halogen; —R 10 is —H or -(1-4C)alkyl; —R 11 is —H; —R 12 is —H, -cyano or -(1-4C)alkyl; —R 13 is —H, -(1-4C)alkyl, -halogen or -formyl; —R 14 is —H, -halogen, -cyano, -(1-4C)alkyl or -(hetero)aryl; or a pharmaceutically acceptable salt thereof. The compounds of this invention are highly specific for the glucocorticoid receptor and may be used for treating inflammatory diseases.

  本发明涉及公式（I）的新型氨基酸衍生物，其中R基的含义如下：-R1为-H或-(1-4C)烷基；-R2为-C（O）R15或-S（O）2R15；-R3为-H，-(1-4C)烷基或-OR16；-R4为-H，-(1-4C)烷基或-OR16；-R6为-H或-C（R16）NOR16；-R7为-H，-卤素，-氰基；-(1-6C)烷基，-(2-6C)烯基或-(2-6C)炔基，均可选择地取代-氨基，-羟基或-卤素；-R8为-H，-氰基，-卤素，-硝基；-(1-6C)烷基，-(2-6C)烯基，-(2-6C)炔基或-O（1-6C）烷基，均可选择地取代-氨基，-羟基或-卤素；-(杂)芳基，可选择地取代-氰基，-卤素，-(1-4C)烷基，-(1-4C)烷氧基，-(1-4C)烷氧基（1-4C）烷基或-(杂)芳基；-C（R16）NOR16；-C（O）N（R17）2；-C（O）R18，-C（O）OR19，-NHC（O）R20或-NHS（O）2R21；-R9为-H，-卤素，-氰基或-(1-4C)烷基，可选择地取代-卤素；-R10为-H或-(1-4C)烷基；-R11为-H；-R12为-H，-氰基或-(1-4C)烷基；-R13为-H，-(1-4C)烷基，-卤素或-甲酰基；-R14为-H，-卤素，-氰基，-(1-4C)烷基或-(杂)芳基；或其药学上可接受的盐。本发明的化合物对糖皮质激素受体具有高度特异性，可用于治疗炎症性疾病。
• Non-steroidal compounds useful as glucocorticoid receptor modulators
  申请人：Plate Ralf

  公开号：US08575152B2

  公开（公告）日：2013-11-05

  This invention relates to novel amino acid derivatives of formula (I) wherein the R groups have the following meanings: —R1 is —H or —(1-4C)alkyl; —R2 is —C(O)R15 or —S(O)2R15; —R3 is —H, —(1-4C)alkyl or —OR16; —R4 is —H, —(1-4C)alkyl or —OR16; —R6 is —H or —C(R16)NOR16; —R7 is —H, -halogen, -cyano; —(1-6C)alkyl, —(2-6C)alkenyl or —(2-6C)alkynyl, all optionally substituted with -amino, -hydroxyl or -halogen; —R8 is —H, -cyano, -halogen, -nitro; —(1-6C)alkyl, —(2-6C)alkenyl, —(2-6C)alkynyl or —O(1-6C)alkyl, all optionally substituted with -amino, -hydroxyl or -halogen; -(hetero)aryl, optionally substituted with -cyano, -halogen, —(1-4C)alkyl, —(1-4C)alkoxy, —(1-4C)alkoxy(1-4C)alkyl or -(hetero)aryl; —C(R16)NOR16; —C(O)N(R17)2; —C(O)R18, —C(O)OR19, —NHC(O)R20, or —NHS(O)2R21; —R9 is —H, -halogen, -cyano, or —(1-4C)alkyl, optionally substituted with -halogen; —R10 is —H or —(1-4C)alkyl; —R11 is —H; —R12 is —H, -cyano or —(1-4C)alkyl; —R13 is —H, —(1-4C)alkyl, -halogen or -formyl; —R14 is —H, -halogen, -cyano, —(1-4C)alkyl or -(hetero)aryl; or a pharmaceutically acceptable salt thereof. The compounds of this invention are highly specific for the glucocorticoid receptor and may be used for treating inflammatory diseases.

  本发明涉及公式（I）的新型氨基酸衍生物，其中R基有以下含义：-R1为-H或-（1-4C）烷基；-R2为-C（O）R15或-S（O）2R15；-R3为-H，-（1-4C）烷基或-OR16；-R4为-H，-（1-4C）烷基或-OR16；-R6为-H或-C（R16）NOR16；-R7为-H，-卤素，-氰基；-（1-6C）烷基，-（2-6C）烯基或-（2-6C）炔基，均可选择性地被氨基，-羟基或-卤素取代；-R8为-H，-氰基，-卤素，-硝基；-（1-6C）烷基，-（2-6C）烯基，-（2-6C）炔基或-O（1-6C）烷基，均可选择性地被氨基，-羟基或-卤素取代；-（杂）芳基，可选择性地被氰基，-卤素，-（1-4C）烷基，-（1-4C）烷氧基，-（1-4C）烷氧基（1-4C）烷基或-（杂）芳基取代；-C（R16）NOR16；-C（O）N（R17）2；-C（O）R18，-C（O）OR19，-NHC（O）R20或-NHS（O）2R21；-R9为-H，-卤素，-氰基或-（1-4C）烷基，可选择性地被-卤素取代；-R10为-H或-（1-4C）烷基；-R11为-H；-R12为-H，-氰基或-（1-4C）烷基；-R13为-H，-（1-4C）烷基，-卤素或-甲酰基；-R14为-H，-卤素，-氰基，-（1-4C）烷基或-（杂）芳基；或其药学上可接受的盐。本发明的化合物对糖皮质激素受体具有高度特异性，可用于治疗炎症性疾病。
• SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG
  申请人：Shionogi & Co., Ltd.

  公开号：EP2620436A1

  公开（公告）日：2013-07-31

  The present invention provides a compound having antiviral effects, particularly having growth inhibitory activity on influenza viruses, a preferred example of the compound being a substituted 3 - hydroxy-4-pyridone derivative prodrug having cap-dependent endonuclease inhibitory activity.

  本发明提供了一种具有抗病毒作用，特别是对流感病毒具有生长抑制活性的化合物，该化合物的一个优选实例是一种具有帽依赖性内切酶抑制活性的取代 3-羟基-4-吡啶酮衍生物原药。
• ARENAVIRUS GROWTH INHIBITOR COMPRISING POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE
  申请人：National University Corporation Hokkaido University

  公开号：EP3815689A1

  公开（公告）日：2021-05-05

  The present invention provides a compound having antiviral activity, especially having arenavirus proliferation inhibitory activity, and/or a medicament comprising the compound. More preferably, the present invention provides a compound having proliferation inhibitory activity on the Old World arenaviruses such as Luna virus, Lassa virus, and lymphocytic choriomeningitis virus and/or the New World arenaviruses such as Junin virus, and/or a medicament comprising the compound. An arenavirus proliferation inhibitor comprising a compound represented by Formula (I) or a prodrug thereof or a pharmaceutically acceptable salt thereof: (wherein R1 is carboxy, or the like; A3 is CR2 or N; R2 is a hydrogen atom, halogen, hydroxy, or the like; R3 is a hydrogen atom, hydroxy, carboxy, cyano, formyl, alkyl optionally substituted with Substituent group F, or the like; either A1 or A2 is CR5R6, and the other is NR7, or A1 is CR8R9, and A2 is CR10R11; and R5, R6, R7, R8, R9, R10, and R11 are each independently a hydrogen atom, carboxy, cyano, alkyl optionally substituted with Substituent group F, or the like).

  本发明提供了一种具有抗病毒活性的化合物，尤其是具有抑制禽流感病毒增殖活性的化合物，和/或包含该化合物的药物。更优选地，本发明提供了一种化合物，该化合物对旧大陆病毒（如卢纳病毒、拉萨病毒和淋巴细胞色素膜炎病毒）和/或新大陆病毒（如朱宁病毒）具有增殖抑制活性，和/或包含该化合物的药物。 一种由式（I）代表的化合物或其原药或其药学上可接受的盐组成的腺病毒增殖抑制剂： (其中 R1 是羧基或类似物；A3 是 CR2 或 N；R2 是氢原子、卤素、羟基或类似物；R3 是氢原子、羟基、羧基、氰基、甲酰基、任选被取代基 F 取代的烷基或类似物；A1 或 A2 是 CR5R6，另一个是 NR7，或 A1 是 CR8R9，A2 是 CR10R11；以及 R5、R6、R7、R8、R9、R10 和 R11 各自独立地是氢原子、羧基、氰基、任选被取代基 F 取代的烷基或类似基团）。
• Substituted polycyclic carbamoyl pyridone derivative prodrug
  申请人：Shionogi & Co., Ltd.

  公开号：US10202379B2

  公开（公告）日：2019-02-12

  The present invention provides a compound having antiviral effects, particularly having growth inhibitory activity on influenza viruses, a preferred example of the compound being a substituted 3-hydroxy-4-pyridone derivative prodrug having cap-dependent endonuclease inhibitory activity.

  本发明提供了一种具有抗病毒作用，特别是对流感病毒具有生长抑制活性的化合物，该化合物的一个优选实例是具有帽依赖性内切酶抑制活性的取代 3-羟基-4-吡啶酮衍生物原药。