11-(4-chlorophenyl)-4,4-diphenyl-10-oxa-1,6-diazabicyclo[9.2.2]pentadecan-5-one | 1424272-67-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 11-(4-chlorophenyl)-4,4-diphenyl-10-oxa-1,6-diazabicyclo[9.2.2]pentadecan-5-one
• 英文别名: 11-(4-Chlorophenyl)-4,4-diphenyl-10-oxa-1,6-diazabicyclo[9.2.2]pentadecan-5-one
• CAS: 1424272-67-2
• 化学式: C₃₀H₃₃ClN₂O₂
• 分子量: 489.057
• InChiKey: FIGOLEZNTNROOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  35
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-(4-氯苯基)-4-羟基哌啶 在 sodium hydride 、 N,N-二异丙基乙胺 、 potassium hydroxide 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 、 叔丁醇 为溶剂， 反应 103.0h， 生成 11-(4-chlorophenyl)-4,4-diphenyl-10-oxa-1,6-diazabicyclo[9.2.2]pentadecan-5-one
  参考文献：
  名称：

  RETRACTED: Radiosynthesis of 18F-labeled N-desmethyl-loperamide analogues for prospective molecular imaging radiotracers

  摘要：

  A simple procedure for preparing fluoroethyl-N-desmethyl-loperamide 4 and its analogue 5 was developed. Standard compound 4 was synthesized in useful yields for radiolabeling analysis. [N-Ethyl-18F]N-desmethyl-loperamide, 3, was rapidly and efficiently labeled with no-carrier added fluorine-18 (t(1/2) = 109.7 min) by treatment of readily prepared [F-18]1-bromo-2-fluoro ethane with a N-desmethyl-loperamide precursor at a consistent 7% radiochemical yield. This procedure was also adapted to the radiosynthesis of 3 by [F-18]ethylene tosylate, but at a lower 3% radiochemical yield. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.12.121

文献信息

• RETRACTED: Radiosynthesis of 18F-labeled N-desmethyl-loperamide analogues for prospective molecular imaging radiotracers
  作者：Xiaofeng Bao、Duliang Liu

  DOI：10.1016/j.tetlet.2012.12.121

  日期：2013.3

  A simple procedure for preparing fluoroethyl-N-desmethyl-loperamide 4 and its analogue 5 was developed. Standard compound 4 was synthesized in useful yields for radiolabeling analysis. [N-Ethyl-18F]N-desmethyl-loperamide, 3, was rapidly and efficiently labeled with no-carrier added fluorine-18 (t(1/2) = 109.7 min) by treatment of readily prepared [F-18]1-bromo-2-fluoro ethane with a N-desmethyl-loperamide precursor at a consistent 7% radiochemical yield. This procedure was also adapted to the radiosynthesis of 3 by [F-18]ethylene tosylate, but at a lower 3% radiochemical yield. (C) 2013 Elsevier Ltd. All rights reserved.