5-{3-[(4-Ethoxyphenyl)amino]-2-hydroxypropyl}-3-methyl-1-oxo-1,5-dihydropyrido[1,2-a]benzimidazole-4-carbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 5-{3-[(4-Ethoxyphenyl)amino]-2-hydroxypropyl}-3-methyl-1-oxo-1,5-dihydropyrido[1,2-a]benzimidazole-4-carbonitrile
• 英文别名: 5-[3-(4-ethoxyanilino)-2-hydroxypropyl]-3-methyl-1-oxopyrido[1,2-a]benzimidazole-4-carbonitrile
• 化学式: C₂₄H₂₄N₄O₃
• 分子量: 416.5
• InChiKey: CDKJKYXMDMEIDH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  88.8
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Small Molecule Inhibitors of Retroviral Assembly & Maturation
  申请人：New York Blood Center

  公开号：EP2335779A1

  公开（公告）日：2011-06-22

  Chemical compounds that disrupt retroviral assembly and maturation are presented herein. More particularly, this disclosure provides small molecule compounds that disrupt the formation and maturation of virus particles and methods of using such small molecules to treat HIV-1 infection.

  本文介绍了能破坏逆转录病毒组装和成熟的化学化合物。更具体地说，本公开提供了能破坏病毒颗粒的形成和成熟的小分子化合物，以及用这种小分子化合物治疗 HIV-1 感染的方法。
• Small Molecule Inhibitors of Retroviral Assembly and Maturation
  申请人：Debnath Asim Kumar

  公开号：US20100035912A1

  公开（公告）日：2010-02-11

  Chemical compounds that disrupt retroviral assembly and maturation are presented herein. More particularly, this disclosure provides small molecule compounds that disrupt the formation and maturation of virus particles and methods of using such small molecules to treat HIV-1 infection.
• COMPOUNDS FOR TREATING DISEASE, FOR ADMINISTERING, AND FOR PHARMACEUTICAL COMPOSITIONS
  申请人：Trent John O.

  公开号：US20130059852A1

  公开（公告）日：2013-03-07

  Some embodiments of this invention include methods for treating disease and methods for administering a compound of Formula (I). In some aspects of the invention, diseases can be treated by administration of compositions comprising a compound of Formula (I). Pharmaceutical compositions of some embodiments of the present invention comprise a compound of Formula (I).
• US8299093B2
  申请人：——

  公开号：US8299093B2

  公开（公告）日：2012-10-30
• US8546439B2
  申请人：——

  公开号：US8546439B2

  公开（公告）日：2013-10-01