6.7-Dichlor-anthrachinon-1-carbonsaeure | 58236-19-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 6.7-Dichlor-anthrachinon-1-carbonsaeure
• 英文别名: 6,7-dichloro-9,10-dioxo-9,10-dihydro-anthracene-1-carboxylic acid；6,7-Dichlor-9,10-dioxo-9,10-dihydro-anthracen-1-carbonsaeure；6,7-Dichloroanthraquinone-1-carboxylic acid；6,7-dichloro-9,10-dioxoanthracene-1-carboxylic acid
• CAS: 58236-19-4
• 化学式: C₁₅H₆Cl₂O₄
• 分子量: 321.116
• InChiKey: LTQQNOCPMNSDJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6.7-Dichlor-anthrachinon-1-carbonsaeure 在 草酰氯 、 溶剂黄146 、 锌 作用下， 以 吡啶 、 苯 为溶剂， 生成 2-Dibutylamino-1-(6,7-dichloro-anthracen-1-yl)-ethanol
  参考文献：
  名称：

  抗疟疾氨基醇II：蒽氨基乙醇和蒽氨基丙醇（1-和9-取代的）。

  摘要：

  描述了七个具有一个，两个或三个另外的取代基的蒽氨基醇的合成。这些化合物包括由取代的蒽醌或由10-氯-9-蒽醛制得的三种1-氨基乙醇，两种9-氨基乙醇和两种9-氨基丙醇。根据先前发表的工作讨论了这些化合物的抗疟活性以及初步的构效关系。

  DOI：

  10.1002/jps.2600641207
• 作为产物：
  描述：

  9,10-dichloro-benz[de]anthracen-7-one 在 chromium(VI) oxide 、 溶剂黄146 作用下， 生成 6.7-Dichlor-anthrachinon-1-carbonsaeure
  参考文献：
  名称：

  Examen de la preuve dans la documentation sur l’anesthésie: enquête et évaluation des articles sur les céphalées obstétricales post-ponction durale

  摘要：

  Purpose: To describe a bibliographic database on the literature of postdural puncture headache (PDPH) in the obstetrical population, to describe the research architecture in this field, and to evaluate the quality of case-control studies, cohort studies, and controlled clinical trials on PDPH.Methods: Computerized bibliographic searches, citation review, and hand searches were conducted to find all relevant citations on incidence, clinical course, prevention, or treatment of PDPH in parturients. The study design and topic(s) covered by each study were evaluated. Case-control studies and cohort studies were evaluated using the Quality Index; clinical trials were evaluated using the Jadad scale.Results: One hundred ninety-six relevant citations were published between 1949 and 1999. Research on PDPH has been increasing rapidly with the majority of studies published in the 1990's. Incidence and prevention were the focus of over half of all citations. Optimal study designs were infrequently utilized. The methodological quality was poor for observational studies (Quality Index 10/29) and clinical trials (Jadad scale 2/5).Conclusion: Although the amount of research on PDPH in parturients is increasing, use of optimal study designs and improvement in methodology is needed.

  DOI：

  10.1007/bf03020418

文献信息

• Examen de la preuve dans la documentation sur l’anesthésie: enquête et évaluation des articles sur les céphalées obstétricales post-ponction durale
  作者：Peter T. -L. Choi、Saramin E. Galinski、Stefan Lucas、Lawrence Takeuchi、Alejandro R. Jadad

  DOI：10.1007/bf03020418

  日期：2002.1

  Purpose: To describe a bibliographic database on the literature of postdural puncture headache (PDPH) in the obstetrical population, to describe the research architecture in this field, and to evaluate the quality of case-control studies, cohort studies, and controlled clinical trials on PDPH.Methods: Computerized bibliographic searches, citation review, and hand searches were conducted to find all relevant citations on incidence, clinical course, prevention, or treatment of PDPH in parturients. The study design and topic(s) covered by each study were evaluated. Case-control studies and cohort studies were evaluated using the Quality Index; clinical trials were evaluated using the Jadad scale.Results: One hundred ninety-six relevant citations were published between 1949 and 1999. Research on PDPH has been increasing rapidly with the majority of studies published in the 1990's. Incidence and prevention were the focus of over half of all citations. Optimal study designs were infrequently utilized. The methodological quality was poor for observational studies (Quality Index 10/29) and clinical trials (Jadad scale 2/5).Conclusion: Although the amount of research on PDPH in parturients is increasing, use of optimal study designs and improvement in methodology is needed.
• Antimalarial Amino Alcohols II: Anthraceneaminoethanols and Anthraceneaminopropanols (1‐ and 9‐Substituted)
  作者：J.T. Traxler、M.J. Moats、E.P. Lira、C.W. Huffman

  DOI：10.1002/jps.2600641207

  日期：1975.12

  The syntheses of seven anthracene amino alcohols with one, two, or three additional substituents are described. These compounds include three 1-aminoethanols, two 9-aminoethanols, and two 9-aminopropanols, prepared from substituted anthraquinones or from 10-chloro-9-anthraldehydes. The antimalarial activity of these compounds, as well as tentative structure-activity relationships, is discussed in the

  描述了七个具有一个，两个或三个另外的取代基的蒽氨基醇的合成。这些化合物包括由取代的蒽醌或由10-氯-9-蒽醛制得的三种1-氨基乙醇，两种9-氨基乙醇和两种9-氨基丙醇。根据先前发表的工作讨论了这些化合物的抗疟活性以及初步的构效关系。