ortho-(R)-N,N-dimethyl-<(dimethyl)-(1-methylethenyl)-silyl>-phenylethylamine | 230949-42-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: ortho-(R)-N,N-dimethyl-<(dimethyl)-(1-methylethenyl)-silyl>-phenylethylamine
• 英文别名: (1R)-1-[2-[dimethyl(prop-1-en-2-yl)silyl]phenyl]-N,N-dimethylethanamine
• CAS: 230949-42-5
• 化学式: C₁₅H₂₅NSi
• 分子量: 247.456
• InChiKey: FBRGGICEGVMAJQ-CYBMUJFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.34
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  吗啉 、 一氧化碳 、 ortho-(R)-N,N-dimethyl-<(dimethyl)-(1-methylethenyl)-silyl>-phenylethylamine 在 [Rh(cod)][BPh₄] 、 氢气 作用下， 以 甲苯 为溶剂， 120.0 ℃ 、10.0 MPa 条件下， 反应 44.0h， 以91%的产率得到ortho-(R)-N,N-dimethyl-<(dimethyl)-(1-methyl-3-(morpholin-4-yl)-propyl)-silyl>-phenylethyl-amine
  参考文献：
  名称：

  One-pot synthesis of β- and γ-aminofunctionalised amines and silanes via hydroaminomethylation of enamines and vinylsilanes

  摘要：

  Heterofunctionalised enamines and vinylsilanes under hydroformylation conditions in the presence of primary or secondary amines are converted to form diamines or aminosilanes in one step. This selective one-pot hydroaminomethylation procedure establishes an easy and convenient access to beta- and gamma-aminofunctionalised amines and silanes with potential biological activity. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00350-6
• 作为产物：
  描述：

  (R)-(+)-N,N-二甲基-1-苯乙胺 在 正丁基锂 、 四甲基乙二胺 作用下， 以 四氢呋喃 、 乙醚 、 正己烷 为溶剂， 反应 120.0h， 生成 ortho-(R)-N,N-dimethyl-<(dimethyl)-(1-methylethenyl)-silyl>-phenylethylamine
  参考文献：
  名称：

  One-pot synthesis of β- and γ-aminofunctionalised amines and silanes via hydroaminomethylation of enamines and vinylsilanes

  摘要：

  Heterofunctionalised enamines and vinylsilanes under hydroformylation conditions in the presence of primary or secondary amines are converted to form diamines or aminosilanes in one step. This selective one-pot hydroaminomethylation procedure establishes an easy and convenient access to beta- and gamma-aminofunctionalised amines and silanes with potential biological activity. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00350-6

文献信息

• One-pot synthesis of β- and γ-aminofunctionalised amines and silanes via hydroaminomethylation of enamines and vinylsilanes
  作者：Lars Bärfacker、Thorsten Rische、Peter Eilbracht

  DOI：10.1016/s0040-4020(99)00350-6

  日期：1999.6

  Heterofunctionalised enamines and vinylsilanes under hydroformylation conditions in the presence of primary or secondary amines are converted to form diamines or aminosilanes in one step. This selective one-pot hydroaminomethylation procedure establishes an easy and convenient access to beta- and gamma-aminofunctionalised amines and silanes with potential biological activity. (C) 1999 Elsevier Science Ltd. All rights reserved.