p-tolyl 3,4-di-O-benzoyl-2-O-levulinoyl-1-thio-β-D-xylopyranoside | 1173995-03-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-tolyl 3,4-di-O-benzoyl-2-O-levulinoyl-1-thio-β-D-xylopyranoside
• 英文别名: [(3R,4S,5R,6S)-4-benzoyloxy-6-(4-methylphenyl)sulfanyl-5-(4-oxopentanoyloxy)oxan-3-yl] benzoate
• CAS: 1173995-03-3
• 化学式: C₃₁H₃₀O₈S
• 分子量: 562.64
• InChiKey: PYVPXSQIEORJGS-BJJDYEEQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  40
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  131
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  p-tolyl 3,4-di-O-benzoyl-2-O-levulinoyl-1-thio-β-D-xylopyranoside 、 丙酮 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 水 为溶剂， 反应 0.08h， 生成
  参考文献：
  名称：

  Facile synthesis of three bidesmosidic oleanolic acid saponins with strong inhibitory activity on pancreatic lipase

  摘要：

  The first synthesis of scabiosaponins E (1), F (2), and G (3), three new oleanolic acid saponins with strong inhibitory activity on pancreatic lipase isolated from the Chinese traditional medicinal herb Scabiosa tschiliensis, was efficiently achieved in an one-pot strategy under the combined use of glycosyl trichloro-acetimidates and p-toluene 1-thioglycosides (STol) as donors. (C) 2009 Published by Elsevier Ltd.

  DOI：

  10.1016/j.carres.2009.04.024
• 作为产物：
  描述：

  p-tolyl 3,4-di-O-benzoyl-1-thio-β-D-xylopyranoside 、 乙酰丙酸 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 以85%的产率得到p-tolyl 3,4-di-O-benzoyl-2-O-levulinoyl-1-thio-β-D-xylopyranoside
  参考文献：
  名称：

  Facile synthesis of three bidesmosidic oleanolic acid saponins with strong inhibitory activity on pancreatic lipase

  摘要：

  The first synthesis of scabiosaponins E (1), F (2), and G (3), three new oleanolic acid saponins with strong inhibitory activity on pancreatic lipase isolated from the Chinese traditional medicinal herb Scabiosa tschiliensis, was efficiently achieved in an one-pot strategy under the combined use of glycosyl trichloro-acetimidates and p-toluene 1-thioglycosides (STol) as donors. (C) 2009 Published by Elsevier Ltd.

  DOI：

  10.1016/j.carres.2009.04.024

文献信息

• Facile synthesis of three bidesmosidic oleanolic acid saponins with strong inhibitory activity on pancreatic lipase
  作者：Tiantian Guo、Qingchao Liu、Peng Wang、Lei Zhang、Wei Zhang、Yingxia Li

  DOI：10.1016/j.carres.2009.04.024

  日期：2009.7

  The first synthesis of scabiosaponins E (1), F (2), and G (3), three new oleanolic acid saponins with strong inhibitory activity on pancreatic lipase isolated from the Chinese traditional medicinal herb Scabiosa tschiliensis, was efficiently achieved in an one-pot strategy under the combined use of glycosyl trichloro-acetimidates and p-toluene 1-thioglycosides (STol) as donors. (C) 2009 Published by Elsevier Ltd.