5-ethyl-2-ethylmercapto-pyrimidine | 98490-18-7

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 5-ethyl-2-ethylmercapto-pyrimidine
• 英文别名: 5-Aethyl-2-aethylmercapto-pyrimidin；5-Ethyl-2-ethylsulfanylpyrimidine；5-ethyl-2-ethylsulfanylpyrimidine
• CAS: 98490-18-7
• 化学式: C₈H₁₂N₂S
• 分子量: 168.263
• InChiKey: JVFQORPAOMCVRV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  51.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-N,N-dimethylamino-2-ethylpropenal 在 盐酸 、 sodium hydroxide 作用下， 生成 5-ethyl-2-ethylmercapto-pyrimidine
  参考文献：
  名称：

  Determinants of Body Composition in Postmenopausal Women

  摘要：

  Background. Little is known about the effects of different levels of long-term physical activity on total body and regional fat and whether hormone replacement therapy interacts with physical activity level to affect body composition in postmenopausal women.Methods. We determined the associations between different levels of habitual physical activity, hormone replacement therapy (HRT), and total and regional body composition in postmenopausal women. Twenty sedentary, 20 active nonathletic, and 23 endurance-trained women (approximately half on HRT) had total and regional body composition assessed by dual-energy x-ray absorptiometry. The athletes and active nonathletic women had been active for the same number of years and the same number of hours per week.Results, The athletes and sedentary women weighed the same, but the active nonathletic groups on and not on HRT weighed 3-12 kg more (p < .05). Athletes had less trunk, arm, leg, and total body fat than sedentary and active nonathletic women (p < .05). Women on HRT tended to have lower total body (p = .07), but not regional, fat values. Linear regression analyses indicated that (V) over dot O-2 max in ml/kg/min was the major independent determinant of total and regional; body fat accounting for 52% to 70% of their variances. Athletes had greater caloric and carbohydrate intake than their less active peers, but all groups had similar protein, fat, saturated fat, monounsaturated fat, and polyunsaturated fat intakes.Conclusions. Intense training, but not low- to moderate-intensity physical activity, is associated with markedly lower levels of total and regional body fat in postmenopausal women. HRT has less of an effect on body composition than intense exercise training in postmenopausal women.

  DOI：

  10.1093/gerona/55.10.m607

文献信息

• [EN] SILANOL BASED THERAPEUTIC PAYLOADS<br/>[FR] CHARGES UTILES THÉRAPEUTIQUES À BASE DE SILANOL
  申请人：BLINKBIO INC

  公开号：WO2017214491A1

  公开（公告）日：2017-12-14

  Described herein in part are silanol based therapeutic payloads comprising a silanol terminus, a divalent spacer moiety, and a drug moiety capable of effecting a target cell or tissue.

  本文部分描述了基于硅醇的治疗载荷，包括硅醇末端、二价间隔基团和能够影响靶细胞或组织的药物基团。
• Determinants of Body Composition in Postmenopausal Women
  作者：J. M. Hagberg、J. M. Zmuda、S. D. McCole、K. S. Rodgers、K. R. Wilund、G. E. Moore

  DOI：10.1093/gerona/55.10.m607

  日期：2000.10.1

  Background. Little is known about the effects of different levels of long-term physical activity on total body and regional fat and whether hormone replacement therapy interacts with physical activity level to affect body composition in postmenopausal women.Methods. We determined the associations between different levels of habitual physical activity, hormone replacement therapy (HRT), and total and regional body composition in postmenopausal women. Twenty sedentary, 20 active nonathletic, and 23 endurance-trained women (approximately half on HRT) had total and regional body composition assessed by dual-energy x-ray absorptiometry. The athletes and active nonathletic women had been active for the same number of years and the same number of hours per week.Results, The athletes and sedentary women weighed the same, but the active nonathletic groups on and not on HRT weighed 3-12 kg more (p < .05). Athletes had less trunk, arm, leg, and total body fat than sedentary and active nonathletic women (p < .05). Women on HRT tended to have lower total body (p = .07), but not regional, fat values. Linear regression analyses indicated that (V) over dot O-2 max in ml/kg/min was the major independent determinant of total and regional; body fat accounting for 52% to 70% of their variances. Athletes had greater caloric and carbohydrate intake than their less active peers, but all groups had similar protein, fat, saturated fat, monounsaturated fat, and polyunsaturated fat intakes.Conclusions. Intense training, but not low- to moderate-intensity physical activity, is associated with markedly lower levels of total and regional body fat in postmenopausal women. HRT has less of an effect on body composition than intense exercise training in postmenopausal women.