4-Amino-5-ethyl-1-propan-2-ylpyrimidin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-Amino-5-ethyl-1-propan-2-ylpyrimidin-2-one
• 英文别名: 4-amino-5-ethyl-1-propan-2-ylpyrimidin-2-one
• 化学式: C₉H₁₅N₃O
• 分子量: 181.23
• InChiKey: JBSJNWJPEWVOQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  58.7
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Nucleotide analogues
  申请人：Singular Genomics Systems, Inc.

  公开号：US10738072B1

  公开（公告）日：2020-08-11

  Disclosed herein, inter alia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.

  本文特别披露了用于核酸测序的化合物、组合物和使用方法。
• Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
  申请人：Ju Jingyue

  公开号：US11085076B2

  公开（公告）日：2021-08-10

  Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

  本文特别披露了用于核酸测序的化合物、组合物及其使用方法。
• Modified nucleotides and uses thereof
  申请人：Singular Genomics Systems, Inc.

  公开号：US11174281B1

  公开（公告）日：2021-11-16

  Disclosed herein, inter alia, are compounds, modified nucleotides, compositions, and methods of using the same.

  本文特别公开了化合物、修饰核苷酸、组合物以及使用它们的方法。
• Methods for long read sequencing
  申请人：Singular Genomics Systems, Inc.

  公开号：US11225688B2

  公开（公告）日：2022-01-18

  Provided herein are methods including alternating series of sequencing cycles and dark extension cycles allowing longer read lengths and addressing disadvantages of traditional nucleic acid sequencing protocols.

  本文提供的方法包括交替进行一系列测序循环和暗延伸循环，从而允许更长的读取长度，并解决了传统核酸测序方案的缺点。
• METHODS FOR LONG READ SEQUENCING
  申请人：Singular Genomics Systems, Inc.

  公开号：US20210189481A1

  公开（公告）日：2021-06-24

  Provided herein are methods including alternating series of sequencing cycles and dark extension cycles allowing longer read lengths and addressing disadvantages of traditional nucleic acid sequencing protocols.