[4-chloro-6-(2,4,6-trimethyl-anilino)-pyrimidin-2-ylsulfanyl]-acetic acid ethyl ester | 50892-19-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: [4-chloro-6-(2,4,6-trimethyl-anilino)-pyrimidin-2-ylsulfanyl]-acetic acid ethyl ester
• 英文别名: [4-Chloro-6-(2,4,6-trimethylanilino)-2-pyrimidinylthio] acetic acid ethyl ester；ethyl 2-[4-chloro-6-(2,4,6-trimethylanilino)pyrimidin-2-yl]sulfanylacetate
• CAS: 50892-19-8
• 化学式: C₁₇H₂₀ClN₃O₂S
• 分子量: 365.884
• InChiKey: CKZJXLPDIZEBLB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  89.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2,4,6-三甲基苯胺 、 ethyl 2-((4,6-dichloropyrimidin-2-yl)sulfanyl)acetate 在 sodium carbonate 作用下， 以 乙醇 、 水 为溶剂， 生成 [4-chloro-6-(2,4,6-trimethyl-anilino)-pyrimidin-2-ylsulfanyl]-acetic acid ethyl ester
  参考文献：
  名称：

  2-PYRIMIDINYLTHIO)ALKANOIC ACIDS, ESTERS, AMIDES AND HYDRAZIDES

  摘要：

  (2-嘧啶基硫)烷酸，酯，酰胺和肼以及各种4-和6-取代衍生物，如下所示的结构式：##SPC1## 其中R和R.sup.2独立为--H或较低的烷基；R.sup.1为--H，-卤素或较低的烷氧基；Z为--OH，OM，较低的烷氧基或--(NH).sub.1 --NH.sub.2，其中p为0至1，M为碱金属，碱土金属或铵阳离子；Y为芳基，氨基或取代氨基基团；m为0至2的整数，在温血动物中表现出抗脂质活性。

  公开号：

  US03940394A1

文献信息

• Compounds, compositions and methods for modulating beta-amyloid production
  申请人：Active Pass Pharmaceuticals, Inc.

  公开号：US20030191144A1

  公开（公告）日：2003-10-09

  Methods and compositions useful in the treatment of amyloidosis and conditions and diseases associated therewith, such as Alzheimer's disease, are provided. The methods involve administering to a subject in need thereof a pharmaceutical composition including one or more agents that modulate PPAR&agr; and/or PPAR&dgr; activity, resulting in an inhibition of &bgr;-amyloid production and/or release from cells of the subject, particularly brain cells.

  提供了在治疗淀粉样变性及相关疾病和病况（如阿尔茨海默病）中有用的方法和组合物。这些方法涉及向需要治疗的对象施用包括一个或多个调节PPAR&agr;和/或PPAR&dgr;活性的药物组合物，导致抑制β-淀粉样蛋白从对象的细胞（尤其是脑细胞）中的产生和/或释放。
• COMPOUNDS, COMPOSITIONS AND METHODS FOR MODULATING BETA-AMYLOID PRODUCTION
  申请人：Active Pass Pharmaceuticals, Inc.

  公开号：EP1399426A2

  公开（公告）日：2004-03-24
• US3940394A
  申请人：——

  公开号：US3940394A

  公开（公告）日：1976-02-24
• [EN] COMPOUNDS, COMPOSITIONS AND METHODS FOR MODULATING DOLLAR G(B)-AMYLOID PRODUCTION<br/>[FR] COMPOSES, COMPOSITIONS ET METHODES DE MODULATION DE LA PRODUCTION DE DOLLAR G(B)-AMYLOIDE
  申请人：ACTIVE PASS PHARMACEUTICALS IN

  公开号：WO2002100836A2

  公开（公告）日：2002-12-19

  Methods and compositions useful in the treatment of amyloidosis and conditions and diseases associated therewith, such as Alzheimer's disease; are provided. The methods involve administering to a subject in need thereof a pharmaceutical composition including one or more agents that modulate PPARα and/or PPARΔ activity, resulting in an inhibition of β-amyloid production and/or release from cells of the subject, particularly brain cells.
• 2-PYRIMIDINYLTHIO)ALKANOIC ACIDS, ESTERS, AMIDES AND HYDRAZIDES
  申请人：——

  公开号：US03940394A1

  公开（公告）日：1976-02-24

  (2-Pyrimidinylthio)alkanoic acid, esters, amides and hydrazides as well as various 4- and 6-substituted derivatives thereof as depicted by the structural formula: ##SPC1## In which R and R.sup.2 are independently --H or lower alkyl; R.sup.1 is --H, -halo or lower alkoxy; Z is --OH, OM, lower alkoxy or --(NH).sub.1 --NH.sub.2, wherein p is 0 to 1 and M is an alkali metal, alkaline earth metal or ammonium cation; Y is an aryl, amino or substituted amino radical; and m is an integer from 0 to 2, exhibit anti-lipemic activity in warm-blooded animals.

  (2-嘧啶基硫)烷酸，酯，酰胺和肼以及各种4-和6-取代衍生物，如下所示的结构式：##SPC1## 其中R和R.sup.2独立为--H或较低的烷基；R.sup.1为--H，-卤素或较低的烷氧基；Z为--OH，OM，较低的烷氧基或--(NH).sub.1 --NH.sub.2，其中p为0至1，M为碱金属，碱土金属或铵阳离子；Y为芳基，氨基或取代氨基基团；m为0至2的整数，在温血动物中表现出抗脂质活性。