2-chloro-9-[(4-methoxyphenyl)methyl]-N-(2,4,6-trimethylphenyl)purin-6-amine | 1322877-97-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-chloro-9-[(4-methoxyphenyl)methyl]-N-(2,4,6-trimethylphenyl)purin-6-amine
• CAS: 1322877-97-3
• 化学式: C₂₂H₂₂ClN₅O
• 分子量: 407.903
• InChiKey: WKMQHCWDYBOTQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  64.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-chloro-9-[(4-methoxyphenyl)methyl]-N-(2,4,6-trimethylphenyl)purin-6-amine 、 对氨基苯腈 在 tris-(dibenzylideneacetone)dipalladium(0) 、 caesium carbonate 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 、 三氟乙酸 作用下， 以 甲苯 为溶剂， 反应 12.0h， 生成 4-[[6-(2,4,6-trimethylanilino)-7H-purin-2-yl]amino]benzonitrile
  参考文献：
  名称：

  Novel Procedure for the Coupling of Sterically Hindered Electron-Deficient Anilines to the 6-Position of the Purine Core

  摘要：

  Sterically hindered electron-deficient anilines are coupled to the 6-position of the purine core only when activated as their corresponding TFA-amide. The free anilines did not react under all conditions tested. After aqueous work-up, the TFA-group is lost.This procedure provides a new tool in the construction of purines functionalized with a sterically hindered electron-deficient aniline in the 6-position.

  DOI：

  10.1080/00397911.2010.517615
• 作为产物：
  描述：

  2,6-二氯嘌呤 在 potassium carbonate 作用下， 以 乙醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 生成 2-chloro-9-[(4-methoxyphenyl)methyl]-N-(2,4,6-trimethylphenyl)purin-6-amine
  参考文献：
  名称：

  Novel Procedure for the Coupling of Sterically Hindered Electron-Deficient Anilines to the 6-Position of the Purine Core

  摘要：

  Sterically hindered electron-deficient anilines are coupled to the 6-position of the purine core only when activated as their corresponding TFA-amide. The free anilines did not react under all conditions tested. After aqueous work-up, the TFA-group is lost.This procedure provides a new tool in the construction of purines functionalized with a sterically hindered electron-deficient aniline in the 6-position.

  DOI：

  10.1080/00397911.2010.517615

文献信息

• Novel Procedure for the Coupling of Sterically Hindered Electron-Deficient Anilines to the 6-Position of the Purine Core
  作者：Ruben Leenders、Jan Heeres、Dirk Vandenput、Jérôme Guillemont、Paul Lewi

  DOI：10.1080/00397911.2010.517615

  日期：2011.11.1

  Sterically hindered electron-deficient anilines are coupled to the 6-position of the purine core only when activated as their corresponding TFA-amide. The free anilines did not react under all conditions tested. After aqueous work-up, the TFA-group is lost.This procedure provides a new tool in the construction of purines functionalized with a sterically hindered electron-deficient aniline in the 6-position.