(4-Methoxyphenyl)-(2-morpholin-4-yl-5-nitrophenyl)methanone | 432527-47-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-Methoxyphenyl)-(2-morpholin-4-yl-5-nitrophenyl)methanone
• CAS: 432527-47-4
• 化学式: C18H18N2O5
• 分子量: 342.3
• InChiKey: AJGUNSPGEMSDLA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  84.6
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Novel pharmaceutical compositions and methods for treating tumors, including drug-resistant tumors
  申请人：Dong Zhongyun

  公开号：US20070054908A1

  公开（公告）日：2007-03-08

  Pharmaceutical compositions comprising a chemotherapeutic agent comprising one of the previously unknown antineoplastic agents, DL-001 or DL-002 and methods for inhibiting tumor cell proliferation, inducing tumor cell death by apoptosis and inhibiting growth of a drug resistant tumor comprising administration of the inventive compositions are provided. Successfully treated tumors include epithelial cell-derived malignancies and a broad spectrum of tumors, including drug resistant tumors. In particular, the inventive compositions retain efficacy in tumors exhibiting multiple drug resistance.
• ANTIMETASTATIC COMPOUNDS
  申请人：Hansen Marc

  公开号：US20130158035A1

  公开（公告）日：2013-06-20

  Screening methods for identifying compounds and compounds and pharmaceutical compositions for treating and preventing cancer are disclosed. The compounds affect signal transduction downstream of the MET receptor.
• [EN] ANTIMETASTATIC COMPOUNDS<br/>[FR] COMPOSÉS ANTIMÉTASTATIQUES
  申请人：UNIV BRIGHAM YOUNG

  公开号：WO2012027392A2

  公开（公告）日：2012-03-01

  Screening methods for identifying compounds and compounds and pharmaceutical compositions for treating and preventing cancer are disclosed. The compounds affect signal transduction downstream of the MET receptor.