3-Hydroxy-N-methyl-phthalimid | 3740-31-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 3-Hydroxy-N-methyl-phthalimid
• 英文别名: 3-Hydroxy-N-methylphthalimide；3-Oxy-N-methyl-phthalimid；4-Hydroxy-2-methylisoindoline-1,3-dione；4-hydroxy-2-methylisoindole-1,3-dione
• CAS: 3740-31-6
• 化学式: C₉H₇NO₃
• 分子量: 177.159
• InChiKey: BJAILBJCGKOBCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-Hydroxy-N-methyl-phthalimid 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以12%的产率得到2-methyl-2,3-dihydro-1H-isoindol-4-ol
  参考文献：
  名称：

  WO2008/51533

  摘要：

  公开号：
• 作为产物：
  描述：

  N-甲基间氨基邻苯二甲酰亚胺 生成 3-Hydroxy-N-methyl-phthalimid
  参考文献：
  名称：

  Tirouflet; Dabard, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1956, vol. 242, p. 916

  摘要：

  DOI：

文献信息

• ANTIALLERGIC AGENTS
  申请人：Muto Susumu

  公开号：US20080090779A1

  公开（公告）日：2008-04-17

  A medicament for the preventive and/or therapeutic treatment of allergic diseases and/or endometriosis and/or hysteromyoma which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof: wherein X represents a connecting group whose number of atoms in the main chain is 2 to 5 (said connecting group may be substituted), A represents hydrogen atom or acetyl group, E represents an aryl group which may be substituted or a hetero aryl group which may be substituted, ring Z represents an arene which may have one or more substituents in addition to the group represented by formula —O-A wherein A has the same meaning as that defined above and the group represented by formula —X-E wherein each of X and E has the same meaning as that defined above, or a heteroarene which may have one or more substituents in addition to the group represented by formula —O-A wherein A has the same meaning as that defined above and the group represented by formula —X-E wherein each of X and E has the same meaning as that defined above.

  一种预防和/或治疗过敏性疾病和/或子宫内膜异位症和/或子宫肌瘤的药物，其包括以下通式（I）所表示的化合物或其药学上可接受的盐、水合物和溶剂化物作为活性成分，其中X表示连接基，其主链中原子数为2至5（该连接基可以被取代），A表示氢原子或乙酰基，E表示芳基或取代的杂芳基，环Z表示苯环，除了由公式-O-A表示的基团，该苯环还可以具有一个或多个取代基团，其中A的含义与上述定义相同，而由公式-X-E表示的基团中，每个X和E的含义也与上述定义相同，或者是一个杂环，除了由公式-O-A表示的基团，该杂环还可以具有一个或多个取代基团，其中A的含义与上述定义相同，而由公式-X-E表示的基团中，每个X和E的含义也与上述定义相同。
• Antiallergic agents
  申请人：Muto Susumu

  公开号：US20070185059A1

  公开（公告）日：2007-08-09

  A medicament for the preventive and/or therapeutic treatment of allergic diseases and/or endometriosis and/or hysteromyoma which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof: wherein X represents a connecting group whose number of atoms in the main chain is 2 to (said connecting group may be substituted), A represents hydrogen atom or acetyl group, E represents an aryl group which may be substituted or a hetero aryl group which may be substituted, ring Z represents an arene which may have one or more substitutents in addition to the group represented by formula —O-A wherein A has the same meaning as that defined above and the group represented by formula —X-E wherein each of X and E has the same meaning as that defined above, or a heteroarene which may have one or more substitutents in addition to the group represented by formula —O-A wherein A has the same meaning as that defined above and the group represented by formula —X-E wherein each of X and E has the same meaning as that defined above.

  一种用于预防和/或治疗过敏性疾病和/或子宫内膜异位症和/或子宫肌瘤的药物，其活性成分包括以下通式（I）表示的化合物或其药学上可接受的盐、水合物和溶剂化物中的一种，其中X代表连接基，其主链中的原子数为2到（该连接基可以被取代），A代表氢原子或乙酰基，E代表芳基或取代的杂环芳基，环Z代表芳烃，除了由公式-O-A表示的基团外，还可以有一个或多个取代基，其中A具有上述定义的相同含义，并且由公式-X-E表示的基团，其中X和E的每个都具有上述定义的相同含义，或者可以有一个或多个取代基的杂芳烃，其中A具有上述定义的相同含义，并且由公式-X-E表示的基团，其中X和E的每个都具有上述定义的相同含义。
• BENZIMIDAZOLE COMPOUNDS
  申请人：Aso Kazuyoshi

  公开号：US20100056515A1

  公开（公告）日：2010-03-04

  There is provided a compound of the formula (I): wherein R 1 is an optionally substituted C 1-10 alkyl; R 2 is H, or a C 1-6 alkyl which may be substituted with 1 to 3 substituents; R 3 is a 5- or 6-membered aromatic group which may be substituted with 1 to 5 substituents, wherein the 5- or 6-membered aromatic group may be fused with a 5- or 6-membered ring which may be substituted with 1 to 3 C 1-6 alkyls; R 4 is a hydrogen, a halogen, a hydroxy, a cyano, a C 1-6 alkyl or a C 1-6 alkoxy; Z is —O—, —S—, —SO—, —SO 2 —, or —NR 5 — wherein R 5 is a hydrogen or a C 1-6 alkyl; or a salt thereof or a prodrug thereof, which have CRF receptor antagonist activity and use thereof.

  提供了一个式子(I)的化合物： 其中，R1是可选取代的C1-10烷基；R2是氢，或者是一个C1-6烷基，该烷基可以用1至3个取代基取代；R3是一个5-或6-成员芳香基团，可以用1至5个取代基取代，其中5-或6-成员芳香基团可以与一个5-或6-成员环融合，该环可以用1至3个C1-6烷基取代；R4是氢、卤素、羟基、氰基、C1-6烷基或C1-6烷氧基；Z是-O-、-S-、-SO-、-SO2-或-NR5-，其中R5是氢或C1-6烷基；或其盐或前药，具有CRF受体拮抗活性和使用方法。
• Probe and dye design through copper-mediated reactions of <i>N</i>-arylhydroxylamines
  作者：Xiaotong Xia、Shuru Liu、Wenming Liu、Qiuying Xu、Ximing Xu、Fang Liu、Tao Deng

  DOI：10.1039/d2ob01595a

  日期：——

  probe (P1) possessing a hydroxylamine group on the benzene ring has been prepared for fluorescence sensing of copper ions. The detection is based on the reaction between hydroxylamine and copper ions, resulting in two fluorescent products through hydroxyl rearrangement and dehydroxylation reactions. P1 shows a specific and sensitive fluorescence response towards copper ions with a limit of detection (LOD)

  制备了苯环上带有羟胺基团的邻苯二甲酰亚胺探针( P1 )用于铜离子的荧光检测。检测是基于羟胺与铜离子之间的反应，通过羟基重排和脱羟基反应产生两种荧光产物。P1显示出对铜离子的特异性和灵敏荧光响应，检测限 (LOD) 为 1.11 nM ( N = 3)。使用P1成功检测了“点击”配体（三（苄基三唑基甲基）胺 (TBTA)）工业来源的铜杂质. 这是首次利用羟胺与铜离子之间的反应。更重要的是，铜介导的羟基重排反应为制备一种在生理条件下具有超小尺寸和亮绿色荧光的新型激发态分子内质子转移 (ESIPT) 染料开辟了道路。
• 3-ARYLOXY-3-ARYL-PROPYLAMINE COMPOUND AND USES THEREOF
  申请人：Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd

  公开号：EP3838900A1

  公开（公告）日：2021-06-23

  A 3-aryloxy-3-aryl-propylamine compound or a pharmaceutically acceptable salt of same, or a prodrug of same, and uses thereof. The compound has the structure of formula I. The compound, the pharmaceutically acceptable salt of same, or the prodrug of same provides an inhibitory effect with respect to a transient receptor potential (TRP) channel protein, and provides great therapeutic effects with respect to diseases related to the transient receptor potential channel protein.

  一种 3-芳氧基-3-芳基-丙胺化合物或其药学上可接受的盐或其原药及其用途。该化合物具有式 I 的结构。该化合物、其药学上可接受的盐或其原药对瞬时受体电位（TRP）通道蛋白有抑制作用，对与瞬时受体电位通道蛋白有关的疾病有很好的治疗效果。