| 1284258-13-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• CAS: 1284258-13-4
• 化学式: C₁₁H₁₇NO₂
• 分子量: 195.261
• InChiKey: KINXBVZNMCNAIL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  在 2,6-二叔丁基-4-甲基苯酚 、 亚碘酰苯 、 1,10-phenanthroline 作用下， 以 二氯甲烷 为溶剂， 以71%的产率得到
  参考文献：
  名称：

  Tunable, Chemoselective Amination via Silver Catalysis

  摘要：

  Organic N-containing compounds, including amines, are essential components of many biologically and pharmaceutically important molecules. One strategy for introducing nitrogen into substrates with multiple reactive bonds is to insert a monovalent N fragment (nitrene or nitrenoid) into a C H bond or add it directly to a C=C bond. However, it has been challenging to develop well-defined catalysts capable of promoting predictable and chemoselective aminations solely through reagent control. Herein, we report remarkable chemoselective aminations that employ a single metal (Ag) and a single ligand (phenanthroline) to promote either aziridination or C H insertion by manipulating the coordination geometry of the active catalysts.

  DOI：

  10.1021/ja406654y

文献信息

• [EN] BICYCLIC METHYLENE AZIRIDINES AND REACTIONS THEREOF<br/>[FR] MÉTHYLÈNE AZIRIDINES BICYCLIQUES ET RÉACTIONS DE CELLES-CI
  申请人：SCHOMAKER JENNIFER

  公开号：WO2013033245A1

  公开（公告）日：2013-03-07

  The oxidative functionalization of olefins is a common method for the formation of vicinal carbon-heteroatom bonds. However, oxidative methods to transform allenes into synthetic motifs containing three contiguous carbon-heteroatom bonds are much less developed. The use of bicyclic methylene aziridines (MAs), prepared via intramolecular allene aziridination, as scaffolds for functionalization of all three allene carbons, among other reactions, is described herein.

  烯烃的氧化官能化是形成邻位碳-杂原子键的常见方法。然而，将联烯转化为含有三个相邻碳-杂原子键的合成基团的氧化方法发展得较少。本文描述了通过分子内联烯氮杂环化制备的双环亚甲基环氮烷（MAs）作为支架，用于官能化所有三个联烯碳原子，以及其他反应。
• Synthesis of Propargylic and Allenic Carbamates <i>via</i> the C–H Amination of Alkynes
  作者：R. David Grigg、Jared W. Rigoli、Simon D. Pearce、Jennifer M. Schomaker

  DOI：10.1021/ol203055v

  日期：2012.1.6

  Propargylic amines are important intermediates for the synthesis of nitrogen-containing heterocycles. The insertion of a nitrene into a propargylic C–H bond has not been explored, despite the attention directed toward the Rh-catalyzed amination of other types of C–H bonds. In this communication, the conversion of a series of homopropargylic carbamates to propargylic carbamates and aminated allenes

  炔丙基胺是合成含氮杂环的重要中间体。尽管已将注意力集中在其他类型的C–H键的Rh催化胺化上，但尚未探索将氮烯插入到炔丙基C–H键中。在这种交流中，描述了一系列的均炔丙基氨基甲酸酯向炔丙基氨基甲酸酯和胺化的烯丙基的转化。
• BICYCLIC METHYLENE AZIRIDINES AND REACTIONS THEREOF
  申请人：Wisconsin Alumni Research Foundation

  公开号：US20160075668A1

  公开（公告）日：2016-03-17

  The oxidative functionalization of olefins is a common method for the formation of vicinal carbon-heteroatom bonds. However, oxidative methods to transform allenes into synthetic motifs containing three contiguous carbon-heteroatom bonds are much less developed. The use of bicyclic methylene aziridines (MAs), prepared via intramolecular allene aziridination, as scaffolds for functionalization of all three allene carbons, among other reactions, is described herein.
• US9221842B2
  申请人：——

  公开号：US9221842B2

  公开（公告）日：2015-12-29
• US9783512B2
  申请人：——

  公开号：US9783512B2

  公开（公告）日：2017-10-10