7-Azidocoumarin

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-Azidocoumarin
• 英文别名: 7-azidochromen-2-one
• 化学式: C9H5N3O2
• 分子量: 187.15
• InChiKey: JASZVBDNVHFEOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  40.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] ENZYMATICALLY-RELEASABLE ARYL DIAZONIUM SPECIES<br/>[FR] ESPÈCE D'ARYLDIAZONIUM À LIBÉRATION ENZYMATIQUE
  申请人：UNIV ARIZONA

  公开号：WO2018165666A1

  公开（公告）日：2018-09-13

  Triazabutadiene molecules and methods of use of triazabutadiene molecules, for example methods and compositions for yielding an aryl diazonium species from a triazabutadiene molecule, e.g., a protected aryl diazonium species in the form of a triazabutadiene. In some embodiments, an enzyme catalyzes the reaction yielding the aryl diazonium species from the triazabutadiene molecule. As an example, the methods and compositions herein may be used for delivery of drugs.

  Triazabutadiene分子及其使用方法，例如从Triazabutadiene分子中产生芳基重氮盐物种的方法和组合物，例如以Triazabutadiene形式的受保护芳基重氮盐物种。在一些实施例中，酶催化从Triazabutadiene分子中产生芳基重氮盐物种的反应。例如，这里的方法和组合物可以用于药物的传递。
• [EN] REDUCTIVE RELEASE PROBES CONTAINING A CHEMOSELECTIVELY CLEAVABLE ALPHA-AZIDOETHER LINKER AND METHODS OF USE THEREOF<br/>[FR] SONDES À LIBÉRATION RÉDUCTRICE CONTENANT UN LIANT ALPHA-AZIDOÉTHER CLIVABLE DE FAÇON CHÉMIOSÉLECTIVE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2011005821A1

  公开（公告）日：2011-01-13

  Probes comprising one or more selectively cleavable α-azidoether moieties are provided; and linkers comprising the one or more selectively cleavable α-azidoether moieties. The α-azidoether moiety will undergo a Staudinger reaction with a suitable reducing agent, resulting in cleavage. The probes find use in a variety of detection assays, e.g. specific polynucleotide binding assays, polypeptide binding assays, etc. The cleavable linkers are suitable for synthetic reactions, e.g. to prepare probes of the invention; in the synthesis of cleavable peptide conjugates; and the like.

  提供了包含一个或多个可选择裂解的α-叠氮醚基团的探针；以及包含一个或多个可选择裂解的α-叠氮醚基团的连接剂。α-叠氮醚基团将与适当的还原剂发生斯陶丁格反应，导致裂解。这些探针可用于各种检测分析中，例如特定多核苷酸结合分析、多肽结合分析等。可裂解的连接剂适用于合成反应，例如用于制备本发明的探针；用于合成可裂解的肽共轭物等。
• COMPOSITIONS AND METHODS FOR BIODETECTION BY NUCLEIC ACID-TEMPLATED CHEMISTRY
  申请人：Huang Yumei

  公开号：US20090275142A1

  公开（公告）日：2009-11-05

  The invention provides compositions and methods for the detection of biological targets, (e.g. nucleic acids and proteins) by nucleic acid-templated chemistry, for example, by generating fluorescent polymethine dyes.

  本发明提供了一种通过核酸模板化学（例如生成荧光聚甲烯染料）检测生物靶标（例如核酸和蛋白质）的组合物和方法。
• REDUCTIVE RELEASE PROBES CONTAINING A CHEMOSELECTIVELY CLEAVABLE ALPHA-AZIDOETHER LINKER AND METHODS OF USE THEREOF
  申请人：Franzini Raphael M.

  公开号：US20120178086A1

  公开（公告）日：2012-07-12

  Probes comprising one or more selectively cleavable α-azidoether moieties are provided; and linkers comprising the one or more selectively cleavable α-azidoether moieties. The α-azidoether moiety will undergo a Staudinger reaction with a suitable reducing agent, resulting in cleavage. The probes find use in a variety of detection assays, e.g. specific polynucleotide binding assays, polypeptide binding assays, etc. The cleavable linkers are suitable for synthetic reactions, e.g. to prepare probes of the invention; in the synthesis of cleavable peptide conjugates; and the like.

  提供了包含一个或多个可选择性裂解的α-叠氮醚基团的探针；以及包含一个或多个可选择性裂解的α-叠氮醚基团的连接体。α-叠氮醚基团将与合适的还原剂发生斯陶丁格反应，导致裂解。这些探针适用于各种检测分析中，例如特定的多核苷酸结合分析、多肽结合分析等。可裂解的连接体适用于合成反应，例如制备本发明的探针；在裂解肽共轭物的合成中使用等。
• Substituted triazenes protected from degradation by carboxylation of N1
  申请人：ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

  公开号：US10472330B2

  公开（公告）日：2019-11-12

  Triazabutadiene molecules for use in applications. e.g., those involving fluorogenic molecules, e.g., triazabutadiene molecules configured to generate a fluorescent compound when combined with a second molecule, e.g., upon reaction with a tyrosine molecule or other appropriate molecule; and protected triazabutadiene molecules that are stable in acidic conditions and are adapted to release an active (e.g., acid-labile} triazabutadiene molecule upon appropriate conditions, and methods for producing and using said protected or releasable triazabutadiene molecules (and products of cleavage).

  应用中使用的三氮杂丁二烯分子，例如，涉及致荧光分子的应用，例如，三氮杂丁二烯分子在与第二种分子（例如，酪氨酸分子或其他适当分子）反应时配置为生成荧光化合物；以及受保护的三氮杂丁二烯分子，这些分子在酸性条件下稳定，并适合释放活性（例如，酪氨酸分子或其他适当分子）、与酪氨酸分子或其他适当分子反应时产生荧光化合物；以及在酸性条件下稳定的受保护的三氮杂丁二烯分子，该分子可在适当条件下释放出活性（例如，酸性可亲和性}三氮杂丁二烯分子，以及生产和使用所述受保护或可释放的三氮杂丁二烯分子（和裂解产物）的方法。